Biomarker and Antibody Development for Asthma

Creative Biolabs is a well-recognized expert in the field of antibody generation and production. Especially, we have launched a series of in vitro diagnostic (IVD) antibody development services for different infections and diseases. Here, we introduce our antibody development services targeting different biomarkers of asthma.

Asthma

Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurrent symptoms, reversible airflow obstruction and bronchospasm. Asthma has been confirmed as early as ancient Egypt. It usually starts in childhood. Since the 1960s, the incidence of asthma has increased significantly. There is no cure for asthma. Symptoms can be prevented by avoiding triggering factors (such as allergens and irritants) and using inhaled corticosteroids. If asthma symptoms are not controlled, long-acting beta-agonists (LABA) or anti-leukotriene drugs may be used in addition to inhaled corticosteroids. Treatment of rapidly worsening symptoms are usually an inhaled short-acting beta-2 agonist such as salbutamol and oral corticosteroids. In very severe cases, intravenous injections of corticosteroids, magnesium sulfate, and hospitalization may be required.

Diagram of asthma. Fig.1 Diagram of asthma.

Symptoms

Common signs and symptoms of asthma include:

  • Wheezing. A whistling or squeaky sound that occurs when the patient breathes.
  • Coughing. Coughing from asthma often is worse at night or early in the morning, making it hard to sleep. And they may become worse with exercise.
  • Chest tightness. This episode may occur a few times a day or a few times per week.
  • Shortness of breath. Some patients can't catch their breath or feel out of breath.
  • Gastro-esophageal reflux disease (GERD), rhinosinusitis, and obstructive sleep apnea.
  • Psychological disorders.

Risk Factor

Asthma is thought to be caused by a combination of complex and incompletely understood environmental and genetic interactions. It is believed that the recently increased rates of asthma are due to changing epigenetics and a changing living environment.

  • Environmental. Environmental factors include exposure to air pollution, allergens, and other environmental chemicals.
  • Genetic. Family history is a risk factor for asthma, with many different genes being implicated. Some genetic variants may only cause asthma when they are combined with specific environmental exposures.
  • Medicines. Aspirin or other nonsteroidal anti-inflammatory drugs and nonselective beta-blockers.

Diagnosis

There is currently no precise test for the diagnosis, which is typically based on the pattern of symptoms and response to therapy over time. Spirometry is recommended to aid in diagnosis and management, which is the single best test for asthma.

Novel IVD antibodies are required to be developed for the development of diagnostic immunoassays. Scientific progress has resulted in the discovery of novel disease biomarkers to fulfill the need for a quicker, more specific and more accurate diagnosis of asthma. If you are interested in our IVD antibody discovery services, please contact us for more details.

At Creative Biolabs, we offer high-quality IVD antibody development services against different diagnostic biomarkers of asthma, including but not limited to:



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