IVD Antibodies for CD164 Marker

Creative Biolabs is an incomparable provider of in vitro diagnostic (IVD) antibody development services. With years of ample experience and high-end technologies, scientists from Creative Biolabs can provide high-quality IVD antibody and antibody pair development services targeting CD164 marker for diagnoses of several diseases, such as anaphylaxis and cancer.

Sialomucin core protein 24 (CD164) encoded by CD164 gene, also named as endolyn, is an 80-100 kDa transmembrane sialomucin protein. CD164 has an extracellular region made up of two mucin domains bound by a cysteine-rich motif, and the motif is similar to a consensus pattern discovered in growth factor and cytokine receptors. Besides, it has a single-pass transmembrane domain and a 13-amino-acid intracellular region which contains a C-terminal motif allowing target the protein to lysosomes and endosomes. CD164 has a short cytoplasmic tail which is highly N- and O-glycosylated. It is produced by T and B cells, activated basophils, epithelial cells, and hematopoietic progenitor cells. CD164 acts an important role in cell adhesion and proliferation and serves as a negative signaling molecule for hematopoietic progenitor cells. In addition, this protein has been proven to be related to cancer metastasis and myogenic differentiation.

CD164 induction for the tumorigenesis of normal lung epithelial cells. (Chen, et al., 2017)Fig.1 CD164 induction for the tumorigenesis of normal lung epithelial cells.1

Anaphylaxis Biomarker-CD164

Anaphylaxis is a severe, generalized or systemic hypersensitivity reaction that may lead to death and is a growing medical, social, and economic problem. Anaphylaxis usually induces severe situations such as shortness of breath, lightheadedness, vomiting, low blood pressure, and itchy rash. A number of substances may cause anaphylaxis, including foods, medications, insect bites, as well as latex exposure and exercise. Recently, CD164 has been identified as a basophil activation marker, offering new probabilities for solving most current diagnostic demands. It has demonstrated that allergen-induced CD164 up-regulation is an available signal for the diagnosis of pollen allergy. Furthermore, some hopeful data revealed that CD164 might be highly useful in the diagnosis of allergy induced by a number of other allergens, including drug allergens.

Cancer Metastasis and CD164

Bone metastases emerge in about 85% of patients who die as a result of advanced prostate cancer. As for metastasis, hematopoietic stem cells 'home' to the bone marrow. The molecular determinants of stem cell homing have identified to rely on stromal derived factor-1 (CXCL12) mainly, and its receptor CXCR4. CXCL12 strengthens the expression of CD164 mRNA as well as the CD164 protein, expressed by human prostate cancer cell lines under basal situations. Researchers have found that CD164 expression in osseous metastasis is more than that in soft tissue metastasis, most observable when compared to those found in the liver and lymph nodes. CD164 serves an essential role in localizing tumors not only to sites where there are high levels of CXCL12 expression but also to specific tissue locales.

Human prostate tissue samples stained with CD164. (Havens, et al., 2006)Fig.2 Human prostate tissue samples stained with CD164. Part A is the immunostaining result of benign prostate hyperplasia, B is localized prostate cancer, C is the metastatic prostate cancer to bone marrow. These results indicated that CD164 staining intensity improves with increasing tumor grade.2

With our versatile IVD platform, Creative Biolabs is proud to develop novel CD164-specific antibody from scratch to commercial IVD kit (we can also start with provided antibody candidates). Please feel free to contact us for more information and a detailed quote.

References

  1. Chen, Wei-Liang, et al. "CD164 promotes lung tumor-initiating cells with stem cell activity and determines tumor growth and drug resistance via Akt/mTOR signaling." Oncotarget 8.33 (2017): 54115.
  2. Havens, A. M. (2006). "The role of sialomucin CD164 (MGC-24v or endolyn) in prostate cancer metastasis". BMC cancer 6(1), 1.

For Research Use Only.



Online Inquiry
Name:
*Phone:
*E-mail Address:
*Service & Products Interested:
Project Description:
Contact Us USA

Tel:
Fax:
Email:
UK

Tel:
Email:

Germany

Tel:
Email:

Follow us on:
Copyright © 2024 Creative Biolabs.
Inquiry Basket