An animal model of tumor-associated angiogenesis is a significant strategy to seek for therapeutic agents of human cancers. With our dedicated teams of scientific and project management professionals, Creative Biolabs can provide you various rodent angiogenesis models for your testing of new tumor therapeutic strategies.
What is Angiogenesis?
The process of angiogenesis and anti-angiogenesis are essential to human health since they have a key function of wound healing as well as tissue growth.
Angiogenesis is a multi-step process by which new blood vessels develop from the pre-established vasculature. Angiogenesis is crucial in a considerable physiological and pathological processes, and therefore studying the mechanism of angiogenesis would be an important way to explore the new approaches to the treatment of numerous pathologies.
The followings are considered to play a key role in the complex process of angiogenesis:
a. Proteolytic degradation of the extracellular matrix
b. Directed migration of endothelial cells
c. Proliferation of endothelial cells
d. Deposition of new extracellular matrix
e. Formation of tubules and anastomosis of the newly formed vessels
Tumor Angiogenesis
Cancer cells are abnormal cells that have lost their control in dividing. A malignant tumor includes a population of rapidly dividing and proliferating cancer cells that gradually accumulates mutations. However, tumors require a dedicated blood supply to provide abundant oxygen and other essential nutrients.
Angiogenesis is also an essential step in the transition of tumors from a benign state to a malignant one. The growth of most tumors requires angiogenesis (the formation of new blood vessels). The microenvironment of tumor also induces lymphangiogenic factors that facilitate metastatic spread.
Tumor induces angiogenesis by secreting various growth factors (e.g. VEGF). And growth factors such as bFGF and VEGF can induce capillary growth into the tumor. Angiogenesis enables single cancer cells to break way from an established solid tumor, enter into the blood vessel, and be carried to another distant site where the cancer cells can implant and form a secondary tumor.
Application Fields
The theory of angiogenesis can be divided into two main fields in the modern clinical application: anti-angiogenesis therapies and pro-angiogenic therapies. While the pro-angiogenic therapies are being explored as an optional treatment for cardiovascular diseases; anti-angiogenic therapies are proposed to be used to combat cancer and malignancies, which require abundant oxygen and nutrients to proliferate.
Above all, controlling tumor-associated angiogenesis is a promising strategy for limiting cancer progression. Using animal models to observe angiogenesis is vital to seeking for therapeutic agents which can inhibit angiogenesis in clinic settings. Anti-angiogenic therapy focuses on targeting the growth mechanisms of the tumor vasculature. Since the growth and spread of tumor are exactly angiogenesis-dependent, cancer patients are the persons who would benefit from these therapies.
Creative Biolabs can provide custom angiogenesis models in rodents, such as rat or mouse, for your researching of new tumor therapeutic strategies.
In addition, in order to meet specific requirements and various research objectives of our customs, Creative Biolabs is proud to offer other common types of tumor seeding for you:
If you are interested in learning more about Creative Biolabs' animal models or drug discovery service, please contact us for more information.
For Research Use Only.
