The growth of tumor cells in the subcutaneous space of mouse after implantation has become a general method for assaying tumorigenic potential and evaluating novel anti-cancer agents in vivo. Creative Biolabs offers a panel of subcutaneous tumor models including syngeneic and xenograft both, using our dozens of validated cell lines.
Subcutaneous Tumor Model
Animal models have been widely used as the front line in predicting efficacy and finding toxicities for cancer chemotherapeutic agents before entering the clinic. This has resulted in the development of many different types of animal models of human cancer. Tumor models are demonstrated being useful in identifying novel compounds that subsequently demonstrate significant clinical activity against the appropriate histology. Subcutaneous tumor model is the most popular assessment system for in vivo efficacy evaluation of novel anti-cancer medicine candidates. In general operations, tumor cells are usually subcutaneously implanted on the flank or dorsum of animals (mostly mice or rats), in which the transplanted cells proliferate and form measurable tumors.
Subcutaneous tumor implants are more arduous since the candidate agent have to cross physiologic barriers to reach the target tumor. Furthermore, the subcutaneous models require higher requirements for monitoring and evaluation.
Application Field
Subcutaneously transplanted tumor cells are proved to be a convenient approach to evaluate novel potential anti-cancer drugs in vivo. A wide variety of human and murine cell lines derived from both, including solid tumors and leukemias, while covering a comprehensive gene phenotypes of the tumor, have been adapted to grow in a rodent host and thus allow detection of compounds in the relevant tumor model.
With decades of experience in the industry of animal model and excellent professional skills, Creative Biolabs has established a variety of effective human as well as murine cell lines and offers validated subcutaneous tumor models (both syngeneic and xenograft) for your research on novel anti-cancer drug discovery. In addition, we also provide customized model which can be performed with cell lines provided by our customers.
Following is the list of available commonly used tumor cell lines at Creative Biolabs, which including but not limited to:
In addition, in order to meet specific requirements and various research objectives of our customs, Creative Biolabs is proud to offer other common types of tumor seeding of your choice:
If you are interested in learning more about Creative Biolabs' animal models or drug discovery service, please contact us for further information.
For Research Use Only.
