Apoptosis, a regulated form of cell death, is a fundamental mechanism observed in multicellular organisms. Apoptosis plays an important role in many biological processes, such as immune system homeostasis, and hormone-driven atrophy. Comprehending the underlying mechanism of apoptosis holds significant importance, as it assumes a central role in the therapeutic management of cancer and various other ailments. Consequently, the screening and profiling of apoptosis-related pathways has profound significance for the development of drugs targeting apoptosis-related proteins.
Fig. 1 Apoptosis pathways. (Chaudhry, et al., 2022)
With years of experience and expertise in apoptosis signal pathways, Creative Biolabs succeeds in providing global customers with comprehensive apoptosis screening & profiling services. We have several detection methods to perform apoptosis screening & profiling, one of which is by measuring the fluorescence signal after incubation with an apoptosis target bound to its ligand. Meanwhile, we offer a variety of apoptosis targets-related services to empower clients' drug discovery programs. The amalgamation of our specialist team and extensive range of services ensures that we deliver high-quality data with expeditious turnaround time.
Fig. 2 The bioluminescent annexin assay concept. (Kupcho, et al., 2019)
Fig. 3 The breadth of our apoptosis screening & profiling service. (Creative Biolabs Original)
Fig. 4 Caspase 8. (Creative Biolabs Original)
Caspase-8 overexpression caused apparent apoptosis in HeLa and MCF-7 cells, as shown by annexin V/propidium iodide (PI) flow cytometric studies.
Fig. 5 Annexin V/propidium iodide (PI) flow cytometric results that the initiation of caspase 8 in cancer cells apoptosis. (Zhong, et al., 2020)
Fig. 6 Work with Creative Biolabs. (Creative Biolabs Original)
Creative Biolabs provides best-in-class service that allows for full customization and design from pilot studies to special targeted projects, meaning the service is specifically tailored to answer customers' biological questions. Our competent team, together with our diverse service portfolio, gives us confidence in providing high-quality data in a timely manner.
For more details on our apoptosis screening & profiling service, please feel free to contact us. We are pleased to work together with global customers' attractive projects.
References
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