Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMagnesium transporters are the primary transporting proteins of Mg2+ found in the membrane system of prokaryotes and eukaryotes. Three classes of Mg2+ transport systems have been identified in prokaryotes: CorA (a funnel-shaped homopentamer with two transmembrane helices per monomer), MgtA/B and MgtE. Magnesium transporters move magnesium across the cell membrane, which is essential for the uptake and balance of magnesium in the organism. And magnesium exerts multiple biological processes, such as regulating mitochondrial function and energy metabolism, neuromuscular function, controlling DNA and protein synthesis. Besides, magnesium also can be regarded as a cofactor of other cationic transporters, such as sodium, potassium, and calcium. Studies have shown that lacking intracellular magnesium results in a lot of clinical abnormalities, such as cardiovascular and neurological disorders.
Here show part of magnesium transporters in humans including Angelman syndrome region protein 1 (NIPA1) and Angelman syndrome region protein 1 (NIPA2). NIPA1 may be involved in the regulation of nervous system development and maintenance. NIPA2 may be associated with the regulation of renal magnesium accumulation.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
