Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsPolycystic kidney disease protein family is a group of integral membrane proteins that belong to voltage-gated ion channel superfamily activated by changes in the electrical membrane potential near the channel. There are several transporters ranging from 500 to over 4000 amino acid residues in length and containing 5~18 transmembrane domains in the polycystic kidney disease protein family. Polycystins have been shown to act as cation channels such as Na+, K+ and Ca2+ transporting positive ions across the membrane. Studies have revealed that polycystins are associated with the regulation of organ morphogenesis and function, such as the early development of the metanephric kidney. Mutations in polycystins may be linked to the development of polycystic kidney disease. Hence polycystin channels are proving to be the important new targets for therapy of polycystic kidney disease.
Here shows part of polycystic kidney disease protein family in humans including PKD1, PKD2, PKD1L1, PKD1L3, and PKD2L1. These proteins share sequence and structural homology and are involved in the progression of autosomal dominant polycystic kidney disease. Among polycystins, the functions and structures of PKD1 and PKD2 are relatively clear. PKD1 interacting with PKD2 in renal tubules promotes the normal development and function of the kidneys. Mutations in PKD2 (5~10%) are associated with a slower clinical deterioration of kidney function.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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