Ryanodine receptors (RYRs) are a class of homotetramers of 565-kD subunits with a massive cytoplasmic domain and a cation channel domain near the C-terminus. There are three major mammalian isoforms of ryanodine receptor: RYR-1, RYR-2, and RYR-3, which are found in different tissues. These receptors are involved in different signaling pathways including the release of calcium from the endoplasmic and sarcoplasmic reticulum into the cytosol ryanodine receptors, converting different extracellular stimuli into intracellular calcium signals. RYRs form a group of intracellular calcium channels in various forms of excitable animal tissue such as neurons, muscle cells, and epithelial cells. The ryanodine receptor RYR-2 isoform is the main cellular mediator of calcium-induced calcium release (CICR) in animal cells.
It has been known that RYRs are associated with a number of human diseases. And further understanding of the many modulators of RYR is important in the development of therapeutics for treatment of cardiac and skeletal muscle diseases. We're concerned here with the three RYRs in human for your review.
By utilizing our Magic™ membrane protein production platform, scientists at Creative Biolabs are well-experienced in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, with the stable cell line.
Additionally, our Magic™ membrane protein antibody discovery platform can also assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.