Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsRyanodine receptors (RYRs) are a class of homotetramers of 565-kD subunits with a massive cytoplasmic domain and a cation channel domain near the C-terminus. There are three major mammalian isoforms of ryanodine receptor: RYR-1, RYR-2, and RYR-3, which are found in different tissues. These receptors are involved in different signaling pathways including the release of calcium from the endoplasmic and sarcoplasmic reticulum into the cytosol ryanodine receptors, converting different extracellular stimuli into intracellular calcium signals. RYRs form a group of intracellular calcium channels in various forms of excitable animal tissue such as neurons, muscle cells, and epithelial cells. The ryanodine receptor RYR-2 isoform is the main cellular mediator of calcium-induced calcium release (CICR) in animal cells.
It has been known that RYRs are associated with a number of human diseases. And further understanding of the many modulators of RYR is important in the development of therapeutics for treatment of cardiac and skeletal muscle diseases. We're concerned here with the three RYRs in human for your review.
By utilizing our MemDX™ membrane protein production platform, scientists at Creative Biolabs are well-experienced in providing the preparation services of these targets in required formats using various strategies, including detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, with the stable cell line.
Additionally, our MemDX™ membrane protein antibody discovery platform can also assist in discovering antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, and etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
