Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
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HighlightsThe SLC34 family of sodium-dependent phosphate transporters is a unique class of membrane transport proteins that share no obvious homology with the other solute carrier families, even at the bacterial level. It consists of three members, NaPiIIa (SLC34A1), NaPi-IIb (SLC34A2), and NaPi-IIc (SLC34A3), which mediate the translocation of divalent inorganic phosphate (HPO42-) together with two (NaPi-IIc) or three sodium ions (NaPi-IIa and NaPi-IIb), respectively. Therefore, phosphate transport by NaPi-IIa and NaPi-IIb is electrically produced. There is currently no 3-D structure of the mammalian SLC34 proteins or their bacterial homologs, so all structural information has been derived from indirect biophysical and biochemical studies on wild-type and engineered mutations.
Fig.1 Transport mechanism of SLC34 proteins. (Wagner, 2014)
NaPi-IIa and NaPi-IIc are mainly expressed in the brush border membrane of the proximal tubule, while NaPi-IIb is found in many more organs including liver, lung, the small intestine, and testis. The abundance and activity of these transporters are primarily regulated by changes in their expression on the cell surface and are determined by interactions with proteins involved in scaffolding, trafficking, or intracellular signaling. All three transporters are highly regulated by factors such as dietary phosphate status, hormones like parathyroid hormone, 1,25-OH2 vitamin D3 or FGF23, electrolyte, and acid-base status. The three members of the SLC34 family are associated with phosphaturia, hypophosphatemia, and ectopic organ calcifications.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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