Tumor Organoid and Other TME Component Co-Culture Model for Immuno-Oncology Drug Discovery and Development

Interactions between cancer cells, immune cells, and fibroblasts result in changes within the tumor microenvironment (TME), which further contributes to increased tumor heterogeneity. At Creative Biolabs, we unequivocally offer a tumor organoids and co-culture model with other TME components, providing a physiologically relevant platform to study the intricate interactions between tumors and immune cells.

Tumor Microenvironment (TME)

TME exerts pivotal influences on malignancy initiation, tumor progression, and metastasis. The intricate TME is comprised of stromal-derived cells, abundant immunocytes, and resident or infiltrating vascular structures. TME homeostasis, orchestrated by cellular and humoral components along with multifaceted inflammatory reactions, supports tumor growth as an integral facet of late-stage tumorigenesis. Recreating this intricate milieu in vitro presents a formidable challenge in tumor modeling.

Fig 1. Different organoid co‐culture models are used to simulate the tumor microenvironment.¹

Why Choose Creative Biolabs Tumor Organoid and TME Components Co-Culture Model

Traditional 2D models derived from patient blood or tumor samples fail to robustly preserve the intricate diversity and physical structure of the TME. By co-culturing tumor organoids derived from patients with adaptive immune cells, innate bone marrow cells, cancer-associated fibroblasts, lymphocytes, et al., we have constructed a complex and dynamic tumor organoid-TME co-culture model that facilitates spatiotemporal interactions, enabling systematic analysis of key factors in tumor recognition or anti-tumor immune responses.

Precision medicine

Through co-culturing tumor cells and TME cells from patient sources, our tumor organoid spheres serve as dynamic, highly regulated, and evolving physiological models.

Customizable options

Co-culturing different types of tumor cells with specific TME cells can provide a wider range of models and effectively predict the efficacy of immunotherapy or drugs.

Powerful oncology tools

With various combinations of tumor cell types and TME cells, our model is applicable to drug screening, genomic research, radiotherapy screening, or cancer gene identification.

What We Provide?

Creative Biolabs employs the co-cultivation of cancer organoids with specific TME cells to tailor them for various research objectives and achieve a precise emulation of tumor conditions. By preserving the histological and mutational features of the original tumor, our unique co-culture model of cancer organoids stands as an exquisite choice for your scientific pursuits.

Please feel free to reach out to us for consultations or to discuss specific requirements.

Related Sections:

• Tumor Organoid Monoculture Model for Immuno-Oncology Drug Discovery and Development
• Tumor Organoid and Immune Cell Co-culture Model for Immuno-Oncology Drug Discovery and Development