Tumor Organoid and TCR Cell Co-Culture Model for Immuno-oncology Drug Discovery and Development

The traditional genotype-based precision medicine for cancer still exhibits inherent limitations. To overcome the limitations of traditional research models in oncology, Creative Biolabs introduces a novel and cutting-edge cancer organoid and T cell receptor (TCR) cell co-culture system.

TCR Cells and Oncology

Immune checkpoint blockade and adoptive cell therapy have emerged as efficacious and potent strategies for intervening in tumors. The integration of specific immune cells into tumor tissue models will facilitate the modeling of immune surveillance within the tumor microenvironment, thus rectifying the existing knowledge gap concerning immune function and immune response in conventional research paradigms.

Fig 1. Schematic representation of the experimental workflow.^1,2

Tumor Organoid and TCR Cells Co-Culture Model

Key Features

By integrating disparate sources and classifications of tumor cells with resident TCR cells, our avant-garde organoid co-culture model offers direct applicability in drug screening, genome manipulation, intervention strategies, and preclinical evaluations, and provides evinces enthralling prospects for T cell-mediated tumor immune response research.

Highly available:

Compared to time-consuming and labor-intensive xenograft models, cancer organoids offer superior accessibility for high-throughput screening.

Genetic heterogeneity:

Using tumor cells that have not undergone multiple passages and clone selection, we construct co-culture systems that effectively preserve the original genetic heterogeneity.

Comprehensive platform:

Co-cultured tumor organoids with TCR cells provide a certified and systematic analysis of tumor recognition and immune processes mediated by T cells in individual patients.

Cutting-edge research specimens:

Organoids retain key characteristics of organ biology, providing additional feasibility for cancer immunology research and immunotherapy development.

What We Provide?

Co-culturing tumor organoids with immune cells or TCR-engineered T cells represents a groundbreaking approach that holds immense potential in the realms of immuno-oncology research. Creative Biolabs’ esteemed team of experts has meticulously devised and refined protocols to facilitate the seamless integration of these elements, thereby optimizing the precision and reproducibility of your experimental assays.

Do not hesitate to reach out to us today to commence a dialogue on how we can elevate and expedite the realization of your research objectives.

Related Sections:

• Tumor Organoid Monoculture Model for Immuno-Oncology Drug Discovery and Development
• Tumor Organoid and Immune Cell Co-culture Model for Immuno-Oncology Drug Discovery and Development