Empowered by extensive experience in antibody research and development, Creative Biolabs is confident to introduce anti-membrane protein discovery services using rat phage display approach to our worldwide.
Antibodies, especially anti-membrane protein antibodies, have been widely used for medical and biotechnological purposes. Especially anti-membrane protein antibodies are at the core of therapeutic antibody development, as membrane proteins. Therefore, anti-membrane protein antibody discovery is of great significance in biomedical field. With years of efforts, Creative Biolabs developed a world-leading phage display platform, especially for membrane protein antigens.
As one of the most popular lab animals, rat plays a key role in many biological studies. In comparison with its rodent brother, rats are larger murine which means greater lymphocyte yield and reduced antigen requirement. Moreover, in terms of analogy, rats also produce the IgA, IgD, IgE, IgG and IgM antibody isotypes and recognize a broad range of human proteins as antigens. While the mainly different advantages between mice and rats are that rats can induce the immune response to mouse antigens. In addition, rat antibodies do not have cross-reactions in immune-detection against antigens out of a mouse background, which is shown as a strong point in some sandwich assays. Hence, rat mAbs are considered as an ideal alternative or complement for diverse researchers to acquire wider repertoires and isolate antibodies against challenging targets.
Incorporated with our powerful phage display platform, we are professional in tailoring highly specific, highly affinitive binders using rat immune library construction and screening.
Of note, we also have rich experience in membrane protein immunogen preparation in diverse formats (liposomes, polymers, nanodiscs, designed peptides, DNA immunization, whole cell presentation, etc.). We offer very flexible options, from which we can figure out the best fit for each custom project. According to different properties of antigen design, we also present versatile screening strategies, e.g. solution-sorting screening, solid phase screening, cell-based screening, etc. Every factor and requirement from clients will be taken into consideration to ensure the optimal outcome.
Creative Biolabs is specialized in tailoring superior rat antibodies targeting membrane proteins. We provide one-stop service package to design personalized campaigns based on different projects. With numerous successful cases in anti-ion channel antibody production, anti-GPCR antibody production, and anti-transporter antibody production, we are always ready to leverage our knowledge and technologies to address custom demands. Please feel free to contact us for more details.