This product is a Raji-Luc2 B cell engineering tool based on the Gold nanoparticles (EpCAM aptamer/Epithelial celladhesion molecule) delivery system and CRISPR-based (SHS-291-crRNA:tracrRNA duplex-Cas12-RS-1) genome editor.
| Host Cell | Raji-Luc2 |
| Target | NEUROG3 |
| Insert Clone | 4C2CR |
| Safe Harbor Sites (SHS) | SHS-291 |
| gRNA | crRNA:tracrRNA duplex |
| Nuclease | Cas12 |
| Enhancer | RS-1 (RAD51-stimulatory compound 1) |
| Targeting Strategy | Enzyme responsive |
| Insertion sites | Unproductive heavy chain |
| Vehicles | Gold nanoparticles |
| Ligand/Receptor | EpCAM aptamer/Epithelial cell adhesion molecule |
| Active Agents | [Ru(bpy)2(tip)]2+, RBT |
| Particle Size | ≤900 |
| Charge (mv) | -5 to -75 |
| Total Atom Count | -75000000 |
| Surface Atoms (%) | -0.65 |
| Specific Surface Area (m2/g) | -0.7 |
| Vector Type | RABV |
| Vector Name | BCpCDH8 |
| Targeting Diseases | Lung cancer; Breast cancer; Prostate cancer; Melanoma |
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