Cas No.: 1608127-09-8
PRODUCT INFORMATION
Description
This is a key building block for Antibody-Drug Conjugates (ADCs). It features an Alloc-protected (allyloxycarbonyl) amine, a cathepsin B-cleavable Valine-Citrulline (Val-Cit) dipeptide, and a p-aminobenzyl alcohol (PAB-OH) self-immolative spacer. The Alloc group is an orthogonal protecting group that can be removed with Pd(0). This linker is an intermediate used to construct protease-cleavable ADCs, where the PAB-OH end is typically attached to a drug payload before conjugation to an antibody.
Molecular Weight
463.54
Purity
>96.0%
Formula
C₂₂H₃₃N₅O₆
Product Type
Enzyme Cleavable Linkers for ADC Preparation
Group 1
Other
Group 2
Other
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- Dithiobis(succinimidyl propionate) (DSP) Homobifunctional Crosslinker (CAT#: OLY-1023-YS141)
- Azido-PEG4-acid (CAT#: OLY-1023-YS67)
- 4-N3Pfp-NHS Ester (CAT#: OLY-1023-YS54)
- Biotin-PEG4-hydrazide Biotins Conjugation Reagent (CAT#: OLY-1023-YS205)
- α-Maleimidoacetic Acid-NHS (AMAS) (CAT#: OLY-1023-YS86)
- Methyltetrazine-NHS Ester Copper-Free Click Chemistry Reagent (CAT#: OLY-1023-YS228)
- Dibenzocyclooctyne-S-S-PEG3-biotin Copper-Free Click Chemistry Reagent (CAT#: OLY-1023-YS211)
- Dithiodiglycolic Acid (CAT#: OLY-1023-YS153)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.