Cas No.: 1608127-09-8
PRODUCT INFORMATION
Description
This is a key building block for Antibody-Drug Conjugates (ADCs). It features an Alloc-protected (allyloxycarbonyl) amine, a cathepsin B-cleavable Valine-Citrulline (Val-Cit) dipeptide, and a p-aminobenzyl alcohol (PAB-OH) self-immolative spacer. The Alloc group is an orthogonal protecting group that can be removed with Pd(0). This linker is an intermediate used to construct protease-cleavable ADCs, where the PAB-OH end is typically attached to a drug payload before conjugation to an antibody.
Molecular Weight
463.54
Purity
>96.0%
Formula
C₂₂H₃₃N₅O₆
Product Type
Enzyme Cleavable Linkers for ADC Preparation
Group 1
Other
Group 2
Other
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, -20°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- N-Succinimidyl Bromoacetate Heterobifunctional Crosslinker (CAT#: OLY-1023-YS28)
- Azido-PEG4-acid (CAT#: OLY-1023-YS67)
- 4-Maleimidobutyric Acid Heterobifunctional Crosslinker (CAT#: OLY-1023-YS10)
- Bis-PEG9-NHS Ester PEGylation Crosslinker (CAT#: OLY-1023-YS168)
- Amino-PEG6-acid PEGylation Crosslinker (CAT#: OLY-1023-YS63)
- m-PEG24-maleimide PEGylation Crosslinker (CAT#: OLY-1023-YS246)
- (R)-α-Lipoic Acid Heterobifunctional Crosslinker (CAT#: OLY-1023-YS8)
- N-(2-Hydroxyethyl)maleimide Heterobifunctional Crosslinker (CAT#: OLY-1023-YS7)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.