Di(N-succinimidyl) Pimelate Homobifunctional Crosslinker (CAT#: OLY-1023-YS136)

Description

This is a homobifunctional, amine-reactive crosslinker, similar to DSS but with a shorter spacer. It possesses two N-hydroxysuccinimide (NHS) ester groups separated by a 7-carbon (C7) aliphatic pimelate spacer. NHS esters react efficiently with primary amines (lysines) at pH 7.0-9.0 to form stable, non-cleavable amide bonds. This linker is used for protein-protein interaction studies, providing a slightly shorter crosslinking distance (10.9 Å) than DSS (11.4 Å). Its hydrophobic nature allows it to permeate cell membranes for intracellular crosslinking.

Molecular Weight

354.32

Purity

>98.0%

Formula

C₁₅H₁₈N₂O₈

Product Type

Homobifunctional Crosslinkers

Group 1

NHS

Group 2

NHS

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, -20°C

Molecular Structure