N-(2-Aminoethyl)maleimide Hydrochloride Heterobifunctional Crosslinker (CAT#: OLY-1023-YS90)

Description

This is a heterobifunctional crosslinker with a short spacer. It features a sulfhydryl-reactive maleimide group and a primary amine (as an HCl salt for stability and solubility). The maleimide group specifically targets thiols (cysteines) at pH 6.5-7.5 to form a stable thioether bond. The primary amine can be reacted with various electrophiles, such as NHS esters or isothiocyanates. This linker is commonly used to add a free amine handle to a cysteine-containing peptide or protein, or to conjugate a thiol-containing molecule to an amine-reactive surface.

Molecular Weight

176.60

Purity

>93.0%

Formula

C₆H₈N₂O₂·HCl

Product Type

Heterobifunctional Crosslinkers

Group 1

Maleimide

Group 2

NH₂

Form (20 deg.C)

Solid

Storage Condition

Store under inert gas, 2-8°C

Molecular Structure