N-Succinimidyl 4-(4-Maleimidophenyl)butyrate (SMPB) Heterobifunctional Crosslinker (CAT#: OLY-1023-YS53)
Datasheet MSDSCas No.: 79886-55-8
PRODUCT INFORMATION
Description
SMPB is a non-cleavable, heterobifunctional crosslinker with a relatively long, rigid spacer. It contains an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive maleimide group. The NHS ester reacts efficiently with primary amines (lysines) at pH 7.0-9.0, while the maleimide group targets thiols (cysteines) at pH 6.5-7.5. The linker's 4-(p-maleimidophenyl)butyrate spacer arm is non-cleavable and provides a long, rigid linkage, which can be advantageous when a defined distance is required. It is widely used to link proteins to peptides or drug payloads.
Molecular Weight
356.33
Purity
>97.0%
Formula
C₁₈H₁₆N₂O₆
Product Type
Heterobifunctional Crosslinkers
Group 1
NHS
Group 2
Maleimide
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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