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Recombinant Anti-Ad Fiber Knob x Anti-CD40 Bispecific Antibody (Diabody-CH3)  (CAT#: BSDBC-002)

Recombinant Anti-Ad fiber knob x Anti-CD40 Bispecific Antibody (Diabody-CH3) is a fusion protein of two diabodies connected together by a CH3 region. In a diabody, the two scFvs with short linkers are from anti-Ad fiber knob and anti-CD40 antibodies. The VH and VL domains form an inter-chain pairing. The diabody with different specificities is fused to each of the CH3 chains, which results in 2+2 antigen-binding valency and extends the half-life of this BsAb. This BsAb can retarget of adenoviral vectors to tumour cells. It can be used in cancer gene therapy to transfer a therapeutic gene into tumour cells aiming at selective and efficient cell killing.
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Specifications

Targets
Ad Fiber Knob & CD40
Type
Constant Domain-extended Bispecific Fragments
Species Reactivity
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Acute myeloid leukaemic (AML)

Targets

Target 1
Ad Fiber Knob
Alternative Names
Ad fiber knob; Adenovirus fiber knob; adenovirus fiber protein; knob domain of Ad fiber
Target 2
CD40
Gene ID
UniProt ID
Alternative Names
CD40; CD40 molecule; p50; Bp50; CDW40; TNFRSF5
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.
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