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Recombinant Anti-CD15 x Anti-DENV Bispecific Antibody (scFv-Fc-scFv)  (BSTF-033)

Recombinant Anti-CD15 x Anti-DENV Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-CD15 scFv is fused to the N-terminus of Fc via a hinge region while another anti-DENV scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb is designed for the research of antibody-dependent enhancement (ADE) and dengue virus infection.

Specifications

Targets
CD15 & DENV
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
CD15
Host Animal 1
Mouse
Target 2
DENV
Host Animal 2
Mouse
Application
FuncS
Related Disease
Dengue virus infection

Targets

Target 1
CD15
Gene ID
UniProt ID
Alternative Names
FUT4; fucosyltransferase 4; LeX; CD15; ELFT; FCT3A; FUTIV; SSEA-1; FUC-TIV; 3-FAL; 3-fucosyl-N-acetyllactosamine; stage-specific embryonic antigen-1; Lewis X; X-hapten
Target 2
DENV
Alternative Names
dengue virus; DENV; dengue fever; Flavivirus

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