Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv-IgG) is formed by an IgG and two scFv fragments. The scFvs from an anti-malaria antigen antibody variable domain are respectively connected to the N terminus of the anti-TLR1 IgG heavy chains or light chains to form scFv-(H)IgG or scFv-(L)IgG. It is a type of appended IgGs and has 2+2 antigen-binding valency. This BsAb can retarget professional antigen-presenting cells (APCs) including DCs or NK cells to malaria antigen. It is designed for the research of Malaria therapy.
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