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CD38 & CD59 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-H292 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD38 Human CD59 Human Inquiry
T-BSDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody CD38 Mouse CD59 Mouse Inquiry
SCIGG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scIgG) Human Single chain IgGs CD38 Human CD59 Human Inquiry
SCIGG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scIgG) Human Single chain IgGs CD38 Mouse CD59 Mouse Inquiry
FVTIG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD38 Human CD59 Human Inquiry
FVTIG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig CD38 Mouse CD59 Mouse Inquiry
BSSG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD38 Human CD59 Human Inquiry
BSSG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-IgG) Human scFv-IgG CD38 Mouse CD59 Mouse Inquiry
IGLFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD38 Human CD59 Human Inquiry
IGLFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv CD38 Mouse CD59 Mouse Inquiry
BSGV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD38 Human CD59 Human Inquiry
BSGV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD38 Mouse CD59 Mouse Inquiry
BSDG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD38 Human CD59 Human Inquiry
BSDG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fv-IgG) Human Fv-IgG CD38 Mouse CD59 Mouse Inquiry
BABFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD38 Human CD59 Human Inquiry
BABFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 CD38 Mouse CD59 Mouse Inquiry
FABVC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD38 Human CD59 Human Inquiry
FABVC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc CD38 Mouse CD59 Mouse Inquiry
SCDBC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD38 Human CD59 Human Inquiry
SCDBC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 CD38 Mouse CD59 Mouse Inquiry
BSDBC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD38 Human CD59 Human Inquiry
BSDBC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 CD38 Mouse CD59 Mouse Inquiry
SCDBF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD38 Human CD59 Human Inquiry
SCDBF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc CD38 Mouse CD59 Mouse Inquiry
BSFVF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD38 Human CD59 Human Inquiry
BSFVF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc CD38 Mouse CD59 Mouse Inquiry
BSDBF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD38 Human CD59 Human Inquiry
BSDBF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc CD38 Mouse CD59 Mouse Inquiry
BSTF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD38 Human CD59 Human Inquiry
BSTF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD38 Mouse CD59 Mouse Inquiry
BSCFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Human CD59 Human Inquiry
BSCFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Mouse CD59 Mouse Inquiry
MNAB-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Human CD59 Human Inquiry
MNAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Mouse CD59 Mouse Inquiry
BSFC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Human CD59 Human Inquiry
BSFC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Mouse CD59 Mouse Inquiry
BSCC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Human CD59 Human Inquiry
BSCC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Mouse CD59 Mouse Inquiry
BIBD-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 Human CD59 Human Inquiry
BIBD-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 Mouse CD59 Mouse Inquiry
FABFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Human CD59 Human Inquiry
FABFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Mouse CD59 Mouse Inquiry
MiniB-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 Human CD59 Human Inquiry
MiniB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 Mouse CD59 Mouse Inquiry
SCTB-H184 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 Human CD59 Human Inquiry
SCDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Human CD59 Human Inquiry
FABIG-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Human CD59 Human Inquiry
TRIB-H294 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD38 Human CD59 Human Inquiry
BSIG-H292 Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Human CD59 Human Inquiry
CROSSAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 Human CD59 Human Inquiry
IGFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Human CD59 Human Inquiry
BSDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 Human CD59 Human Inquiry
BSFAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Human CD59 Human Inquiry
BSFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Human CD59 Human Inquiry
SCTB-089 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 Mouse CD59 Mouse Inquiry
SCDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Mouse CD59 Mouse Inquiry
FABIG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Mouse CD59 Mouse Inquiry
TRIB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD38 Mouse CD59 Mouse Inquiry
BSIG-119 Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Mouse CD59 Mouse Inquiry
CROSSAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 Mouse CD59 Mouse Inquiry
IGFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Mouse CD59 Mouse Inquiry
BSDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 Mouse CD59 Mouse Inquiry
BSFAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Mouse CD59 Mouse Inquiry
BSFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Mouse CD59 Mouse Inquiry
BSTF-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv CD19 Mouse CD59 Mouse Inquiry
BSCFV-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Human CD38 Human Inquiry
BSCFV-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD19 Human CD59 Human Inquiry
BSCFV-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD3 Mouse CD38 Mouse Inquiry
BSCFV-120 Recombinant Anti-CD38 x Anti-saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Mouse saporin Mouse Inquiry
BSCFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-Fc CD19 Mouse CD59 Mouse Inquiry
MNAB-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Human CD38 Human Inquiry
MNAB-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD19 Human CD59 Human Inquiry
MNAB-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Miniantibody) Human Miniantibody CD3 Mouse CD38 Mouse Inquiry
MNAB-120 Recombinant Anti-CD38 x Anti-saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Mouse saporin Mouse Inquiry
MNAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Miniantibody) Human Miniantibody CD19 Mouse CD59 Mouse Inquiry
BSFC-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Human CD38 Human Inquiry
BSFC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD19 Human CD59 Human Inquiry
BSFC-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD3 Mouse CD38 Mouse Inquiry
BSFC-120 Recombinant Anti-CD38 x Anti-saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Mouse saporin Mouse Inquiry
BSFC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD19 Mouse CD59 Mouse Inquiry
BSCC-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Human CD38 Human Inquiry
BSCC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD19 Human CD59 Human Inquiry
BSCC-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD3 Mouse CD38 Mouse Inquiry
BSCC-120 Recombinant Anti-CD38 x Anti-saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Mouse saporin Mouse Inquiry
BSCC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD19 Mouse CD59 Mouse Inquiry
BIBD-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Bibody) Human Bibody CD3 Human CD38 Human Inquiry
BIBD-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD19 Human CD59 Human Inquiry
BIBD-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Bibody) Human Bibody CD3 Mouse CD38 Mouse Inquiry
BIBD-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD38 Mouse Saporin Mouse Inquiry
BIBD-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD19 Mouse CD59 Mouse Inquiry
FABFV-H353 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Human CD38 Human Inquiry
FABFV-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 Human CD59 Human Inquiry
FABFV-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 Mouse CD38 Mouse Inquiry
FABFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Mouse Saporin Mouse Inquiry
FABFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 Mouse CD59 Mouse Inquiry
MiniB-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Minibody) Human Minibody CD3 Human CD38 Human Inquiry
MiniB-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD19 Human CD59 Human Inquiry
MiniB-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Minibody) Human Minibody CD3 Mouse CD38 Mouse Inquiry
MiniB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD38 Mouse Saporin Mouse Inquiry
MiniB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD19 Mouse CD59 Mouse Inquiry
SCTB-H118 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Human CD59 Human Inquiry
SCDB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Human CD59 Human Inquiry
FABIG-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Human CD59 Human Inquiry
TRIB-H220 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Human CD59 Human Inquiry
BSIG-H218 Human Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Human CD59 Human Inquiry
CROSSAB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD19 Human CD59 Human Inquiry
IGFV-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Human CD59 Human Inquiry
BSDB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD19 Human CD59 Human Inquiry
BSFAB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Human CD59 Human Inquiry
BSFV-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Human CD59 Human Inquiry
SCTB-018 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 Mouse CD59 Mouse Inquiry
SCDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Mouse Saporin Mouse Inquiry
SCDB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 Mouse CD59 Mouse Inquiry
FABIG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Mouse Saporin Mouse Inquiry
FABIG-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 Mouse CD59 Mouse Inquiry
TRIB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD38 Mouse Saporin Mouse Inquiry
TRIB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv CD19 Mouse CD59 Mouse Inquiry
BSIG-120 Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Mouse Saporin Mouse Inquiry
BSIG-043 Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 Mouse CD59 Mouse Inquiry
CROSSAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD38 Mouse Saporin Mouse Inquiry
CROSSAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD19 Mouse CD59 Mouse Inquiry
IGFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Mouse Saporin Mouse Inquiry
IGFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 Mouse CD59 Mouse Inquiry
BSDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD38 Mouse Saporin Mouse Inquiry
BSDB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD19 Mouse CD59 Mouse Inquiry
BSFAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Mouse Saporin Mouse Inquiry
BSFAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 Mouse CD59 Mouse Inquiry
BSFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Mouse Saporin Mouse Inquiry
BSFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 Mouse CD59 Mouse Inquiry

Background

CD38 is a transmembrane glycoprotein found on a variety of immune cells such as T cells, B cells, and natural killer cells. It plays a role in cell signaling, immune response regulation, and antibody production. CD59, also known as protectin, is a glycosylphosphatidylinositol-anchored protein that suppresses the formation of the complement system's membrane attack complex (MAC). It protects cells from complement-mediated damage and lysis. The anti-CD38×anti-CD59 bispecific antibody (BsAb) can be constructed to simultaneously bind to CD38-expressing immune cells and CD59 on target cells, modulating immune responses and complement activation. The mechanism of this BsAb supposedly involves enhancing immune cell-mediated cytotoxicity against CD59-expressing target cells and blocking the inhibitory function of CD59 on MAC formation. This BsAb has potential applications in the research of hematological malignancies like multiple myeloma.

Fig.1 CD38 and CD59 structures. (Liu, et al., 2005; Karbian, et al., 2018) Fig.1 The structures of CD38 and CD59.1,2

References

  1. Liu, Qun, et al. "Crystal structure of human CD38 extracellular domain." Structure 13.9 (2005): 1331-1339.
  2. Karbian, Netanel, et al. "Molecular pathogenesis of human CD59 deficiency." Neurology Genetics 4.6 (2018).
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