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CD38 & CD59 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Target 2 INQUIRY
T-BSDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Diabody) Human CD38 CD59 Inquiry
T-BSDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Diabody) Human CD38 CD59 Inquiry
SCIGG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scIgG) Human Single chain IgGs CD38 CD59 Inquiry
SCIGG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scIgG) Human Single chain IgGs CD38 CD59 Inquiry
FVTIG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv4-Ig) Human Appended IgGs CD38 CD59 Inquiry
FVTIG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv4-Ig) Human Appended IgGs CD38 CD59 Inquiry
BSSG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-IgG) Human Appended IgGs CD38 CD59 Inquiry
BSSG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-IgG) Human Appended IgGs CD38 CD59 Inquiry
IGLFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs CD38 CD59 Inquiry
IGLFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG(L)-scFv) Human Appended IgGs CD38 CD59 Inquiry
BSGV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD38 CD59 Inquiry
BSGV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-Fv) Human IgG-Fv CD38 CD59 Inquiry
BSDG-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fv-IgG) Human Appended IgGs CD38 CD59 Inquiry
BSDG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fv-IgG) Human Appended IgGs CD38 CD59 Inquiry
BABFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD38 CD59 Inquiry
BABFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (F(ab')2-scFv2) Human Fab-Fc Fusion Proteins CD38 CD59 Inquiry
FABVC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD38 CD59 Inquiry
FABVC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-scFv-Fc) Human Fab-Fc Fusion Proteins CD38 CD59 Inquiry
SCDBC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
SCDBC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scDiabody-CH3) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
BSDBC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
BSDBC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody-CH3) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
SCDBF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
SCDBF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scDiabody-Fc) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
BSFVF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
BSFVF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv-Fc) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
BSDBF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
BSDBF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody-Fc) Human Constant Domain-extended Bispecific Fragments CD38 CD59 Inquiry
BSTF-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSTF-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSCFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSCFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
MNAB-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
MNAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSFC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSFC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSCC-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BSCC-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD38 CD59 Inquiry
BIBD-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 CD59 Inquiry
BIBD-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD38 CD59 Inquiry
FABFV-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 CD59 Inquiry
FABFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 CD59 Inquiry
MiniB-H294 Recombinant Human Anti-CD38 x Human Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 CD59 Inquiry
MiniB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD38 CD59 Inquiry
SCTB-H184 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 CD59 Inquiry
SCDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 CD59 Inquiry
FABIG-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 CD59 Inquiry
TRIB-H294 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Triple Body) Human Triple Body CD38 CD59 Inquiry
BSIG-H292 Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 CD59 Inquiry
CROSSAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 CD59 Inquiry
IGFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 CD59 Inquiry
BSDB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 CD59 Inquiry
BSFAB-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 CD59 Inquiry
BSFV-H292 Recombinant Human Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 CD59 Inquiry
SCTB-089 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD38 CD59 Inquiry
SCDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 CD59 Inquiry
FABIG-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 CD59 Inquiry
TRIB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Triple Body) Human Triple Body CD38 CD59 Inquiry
BSIG-119 Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 CD59 Inquiry
CROSSAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD38 CD59 Inquiry
IGFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 CD59 Inquiry
BSDB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD38 CD59 Inquiry
BSFAB-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 CD59 Inquiry
BSFV-119 Recombinant Anti-CD38 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 CD59 Inquiry
BSTF-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-Fc-scFv) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
BSCFV-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSCFV-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
BSCFV-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSCFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-Fc) Human scFv-Fc CD38 Saporin Inquiry
BSCFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-Fc) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
MNAB-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
MNAB-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
MNAB-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
MNAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Miniantibody) Human Miniantibody CD38 Saporin Inquiry
MNAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Miniantibody) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
BSFC-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSFC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
BSFC-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSFC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-CH3) Human scFv-CH3 CD38 Saporin Inquiry
BSFC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-CH3) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
BSCC-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSCC-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
BSCC-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD3 CD38 Inquiry
BSCC-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL CD38 Saporin Inquiry
BSCC-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (scFv-CH1/CL) Human scFv-based Bispecific Fragments CD19 CD59 Inquiry
BIBD-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Bibody) Human Bibody CD3 CD38 Inquiry
BIBD-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD19 CD59 Inquiry
BIBD-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Bibody) Human Bibody CD3 CD38 Inquiry
BIBD-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Bibody) Human Bibody CD38 Saporin Inquiry
BIBD-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Bibody) Human Bibody CD19 CD59 Inquiry
FABFV-H353 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 CD38 Inquiry
FABFV-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 CD59 Inquiry
FABFV-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD3 CD38 Inquiry
FABFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-Fv) Human Fab-Fv CD38 Saporin Inquiry
FABFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-Fv) Human Fab-Fv CD19 CD59 Inquiry
MiniB-H354 Recombinant Human Anti-CD3 x Human Anti-CD38 Bispecific Antibody (Minibody) Human Minibody CD3 CD38 Inquiry
MiniB-H220 Recombinant Human Anti-CD19 x Human Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD19 CD59 Inquiry
MiniB-192 Recombinant Anti-CD3 x Anti-CD38 Bispecific Antibody (Minibody) Human Minibody CD3 CD38 Inquiry
MiniB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Minibody) Human Minibody CD38 Saporin Inquiry
MiniB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Minibody) Human Minibody CD19 CD59 Inquiry
SCTB-H118 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 CD59 Inquiry
SCDB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 CD59 Inquiry
FABIG-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 CD59 Inquiry
TRIB-H220 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Triple Body) Human Triple Body CD19 CD59 Inquiry
BSIG-H218 Human Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 CD59 Inquiry
CROSSAB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD19 CD59 Inquiry
IGFV-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 CD59 Inquiry
BSDB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD19 CD59 Inquiry
BSFAB-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 CD59 Inquiry
BSFV-H218 Recombinant Human Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 CD59 Inquiry
SCTB-018 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Triplebody) Human Single-chain Triplebody CD19 CD59 Inquiry
SCDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD38 Saporin Inquiry
SCDB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody CD19 CD59 Inquiry
FABIG-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Fab-IgG) Human Fab-IgG CD38 Saporin Inquiry
FABIG-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Fab-IgG) Human Fab-IgG CD19 CD59 Inquiry
TRIB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Triple Body) Human Triple Body CD38 Saporin Inquiry
TRIB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Triple Body) Human Triple Body CD19 CD59 Inquiry
BSIG-120 Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-IgG) Human IgG-IgG CD38 Saporin Inquiry
BSIG-043 Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-IgG) Human IgG-IgG CD19 CD59 Inquiry
CROSSAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (CrossMab) Human CrossMab CD38 Saporin Inquiry
CROSSAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (CrossMab) Human CrossMab CD19 CD59 Inquiry
IGFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (IgG-scFv) Human IgG-scFv CD38 Saporin Inquiry
IGFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (IgG-scFv) Human IgG-scFv CD19 CD59 Inquiry
BSDB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Diabody) Human Diabody CD38 Saporin Inquiry
BSDB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Diabody) Human Diabody CD19 CD59 Inquiry
BSFAB-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem Fab) Human Tandem Fab CD38 Saporin Inquiry
BSFAB-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem Fab) Human Tandem Fab CD19 CD59 Inquiry
BSFV-120 Recombinant Anti-CD38 x Anti-Saporin Bispecific Antibody (Tandem scFv) Human Tandem scFv CD38 Saporin Inquiry
BSFV-043 Recombinant Anti-CD19 x Anti-CD59 Bispecific Antibody (Tandem scFv) Human Tandem scFv CD19 CD59 Inquiry

Background

CD38 is a transmembrane glycoprotein found on a variety of immune cells such as T cells, B cells, and natural killer cells. It plays a role in cell signaling, immune response regulation, and antibody production. CD59, also known as protectin, is a glycosylphosphatidylinositol-anchored protein that suppresses the formation of the complement system's membrane attack complex (MAC). It protects cells from complement-mediated damage and lysis. The anti-CD38×anti-CD59 bispecific antibody (BsAb) can be constructed to simultaneously bind to CD38-expressing immune cells and CD59 on target cells, modulating immune responses and complement activation. The mechanism of this BsAb supposedly involves enhancing immune cell-mediated cytotoxicity against CD59-expressing target cells and blocking the inhibitory function of CD59 on MAC formation. This BsAb has potential applications in the research of hematological malignancies like multiple myeloma.

Fig.1 CD38 and CD59 structures. (Liu, et al., 2005; Karbian, et al., 2018) Fig.1 The structures of CD38 and CD59.1,2

References

  1. Liu, Qun, et al. "Crystal structure of human CD38 extracellular domain." Structure 13.9 (2005): 1331-1339.
  2. Karbian, Netanel, et al. "Molecular pathogenesis of human CD59 deficiency." Neurology Genetics 4.6 (2018).
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