Creative Biolabs is a well-recognized expert in the field of antibody generation and production. Especially, we have launched a series of in vitro diagnostic (IVD) antibody and immunoassay development services targeting various disease targets. Here, we focus on the periostin biomarker, the diagnostic value of which has been reported in different studies.
Periostin, also known as osteoblast-specific factor2, is a multiple functional matricellular protein that is responsible for mediating biological processes such as cell proliferation, cell differentiation, and cell invasion. The periostin protein, consisting of 836 amino acids in length, is encoded by the POSTN gene. Structurally, periostin has a signal peptide, an EMI domain, four fasciclin-like domains, as well as a C-terminal region. Periostin can be expressed in a wide variety of tissues, especially in the periosteum, and thereby it plays an essential role in regulating bone growth. Besides, periostin is also expressed in several connective tissues, including heart valves, periodontal ligaments, as well as tendons. Furthermore, studies have shown that periostin is related to various diseases, such as breast cancer, colorectal cancer, as well as childhood asthma.
Studies have reported the diagnostic potential of periostin for asthma and pediatric asthma. Mohammed et al. (2018) estimated the serum periostin level in patients with bronchial asthma to evaluate its role in diagnosis using an enzyme-linked immunosorbent assay (ELISA). The results showed that serum periostin was significantly higher in the asthmatic group (atopic and non-atopic) in comparison to the control group. Inoue et al. (2016) assessed the serum periostin levels of asthma in children with asthma and found that serum periostin levels were significantly higher in the asthma groups than the control groups.
Fig.1 Periostin is involved in the pathogenic process of eosinophils and Th2-type asthma.1
Periostin has been reported to be overexpressed in numerous cancers and its diagnostic and prognostic role has been evaluated as well. For instance, Xu et al. (2017) explored the diagnostic and prognostic value of serum periostin by measuring its level in patients with non-small cell lung cancer (NSCLC), benign lung diseases (BLD), and healthy controls. The results showed that levels of serum periostin in NSCLC patients were significantly elevated compared with those in healthy controls and BLD patients. Dong et al. (2018) measured the serum levels of periostin and several other biomarkers in patients with colorectal cancer (CRC). They found serum periostin levels were significantly higher in patients with CRC and was comparable to other commonly used biomarkers.
Antibody-based immunoassays are widely used for detecting and quantifying antigens of interest in different samples such as the serum, urine, tissue preparations, etc. At Creative Biolabs, we offer high-quality target-specific IVD antibody & immunoassay development services to global clients, covering antigen production, antibody development, labeling, and conjugation, as well as immunoassay development. For more information, please click the following links:
Supported by our highly specialized scientists and advanced platform, we are confident in providing services with the best quality and the most competitive prices. Contact us to discuss your project and experience the great value of our services.
References
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