As a leading CRO of antibody generation and development, Creative Biolabs offers application-specific antibody development services to global clients. With experienced scientists and advanced technology, we have established a series of high-quality in vitro diagnostic (IVD) antibody development services against biomarkers of different diseases. Here, we introduce our IVD antibody development services for human papillomavirus (HPV).

Introduction of HPV

Human papillomavirus (HPV) is a small non-enveloped virus with an icosahedral capsid and contains a double-stranded DNA genome. The virus is epitheliotropic and infects mucosal or cutaneous epithelium. Over the past years, more than 180 different HPV strains have been identified and are classified into genera, species, types, and variants. HPVs give rise to a large spectrum of epithelial lesions, ranging from benign hyperplasia with the low malignant potential to precancerous lesions having high malignant potential. Among these HPV strains, HPV-1, 2 and 4 are associated with common warts, whereas HPV-6 and 11 are associated with respiratory papillomas. Furthermore, there is also a subgroup of HPVs, the 'high-risk' HPVs (HPV-16, 18, 33 and 35) which are associated with precancerous lesions.

Structure of Human papillomavirus Fig.1 Structure of Human papilloma virus

Correlation of HPV and STDs

Human papillomavirus (HPV) is a major risk factor for several types of cancer including oropharyngeal cancer. Despite the availability of a prophylactic vaccine, the incidence of HPV-driven oropharyngeal cancer continues to increase. Most papillomavirus infections are transmitted by close contact with either skin to skin or mucosa to mucosa. Studies have suggested that digital-genital and oral-genital contacts can result in the transmission of HPV, although in a relatively low proportion. In addition, vertical transmission from mother to fetus is a common route of infection. Most importantly, it has been reported that human papillomavirus has an important role in male infertility. Women with transient infections often develop cytological abnormalities that take place while there is active HPV replication.

HPV lifecycle Fig.2 HPV lifecycle.

IVD Antibody Development Services for HPV

Nowadays, IVD technology is undergoing rapid development. IVD antibodies have been widely used in immunodiagnostic kits for the diagnosis of various diseases. With cutting-edge technology and advanced IVD platform, Creative Biolabs provides a full range of IVD antibody development services for different infectious disease biomarkers. Especially, we offer IVD antibody development services for HPV. Besides antibody generation, Creative Biolabs also offers diagnostic immunoassay development services, covering feasibility analysis, assay design, assay protocol establishment, assay validation, and kit production.

If you are interested in the services we offer, please don't hesitate to contact us and get a quote. We will get in touch with you as soon as possible.

Reference

  1. Martinez G G, Troconis J N. (2014). “Natural history of the infection for human papillomavirus: an actualization.” Investigacion Clinica, 55(1): 82-91.

For Research Use Only.



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