Drawing upon years of experience in merging particles and antibodies, Creative Biolabs extends globally exceptional, efficient, and cost-effective particle coupling services, tailored to specific needs. Our repertoire includes various particle couplings-colloidal gold, colored or uncolored latex, fluorescent latex, nanoparticles, and magnetic particles, among others. These services are available for inclusion in IVD project development or as independent, standalone offerings.

Particle Conjugation and Application

Microspheres stand as fundamental raw materials crucial to the technology employed in protein and nucleic acid detection analysis. Their pivotal role spans a wide array of fundamental fields due to their distinct sizes and specific structures. With varied functions contingent upon particle size and morphology, microspheres play a diverse role. The evolution of detection methods based on microspheres over recent decades has established them as a pivotal tool in IVD and life sciences.

Schematic of multiplex antibody conjugation onto single nanoparticles. (Kumar, et al., 2008)Fig.1 Schematic of multiplex antibody conjugation onto single nanoparticles.1

In accordance with microsphere structure, categorization reveals three distinct types: porous microspheres, double-layer microspheres, and magnetic microspheres. Presently, diverse microspheres find extensive applications across a spectrum of fields, including biomedicine, cytology, and separation engineering. Noteworthy microsphere properties encompass stability, biocompatibility, functional group attributes, surface characteristics, volume effects, and more.

Porous Microspheres
There are many kinds of porous microspheres, including: polystyrene microspheres, polyurethane microspheres, glass microspheres, ceramic microspheres, etc. Different kinds of porous microspheres have different characteristics. The adsorption of porous microspheres has been widely used in medicine and environmental protection.
Double-layer Microspheres
Double-layer microspheres with core-shell structure play an important role in the field of medicine and biomedical engineering because of their special structure and variable properties. For example, in pharmaceutical applications, a biodegradable polymer material is mixed with a drug as a microsphere core, and another biodegradable polymer material is a shell.
Magnetic Microspheres
Magnetic microspheres can not only be endowed with surface functional groups (such as -OH, -COOH, -CHO, -NH2, etc.) by copolymerization and surface modification, but also have guiding functions under the action of external magnetic fields, which are widely used in many fields such as biomedicine, cytology, and separation engineering.

Particle Conjugation Services Provided by Creative Biolabs

Creative Biolabs can provide a number of particle conjugation services for in vivo biomedical imaging, targeted drug delivery, and many other applications, which include but are not limited to:

Colloidal gold Colored or uncolored latex Fluorescent latex
Nanoparticles Magnetic particles Porous carbon microspheres
polymeric microsphere Natural polymer microspheres SiO2 microspheres

Competitive Advantages of Our Services

  • Expert Technical Guidance: Profound expertise and extensive experience in biomaterial conjugation.
  • Adaptive Service Offerings: Tailored projects and a diverse array of particles.
  • Premium Quality Services: Conjugation services are characterized by precision at competitive rates.

Our tailored particle conjugation service combines flexibility, reproducibility, and quality assurance, leveraging advanced technology and the expertise of seasoned scientists. For detailed information about how we can fulfill your project requirements, please contact us.

Reference

  1. Kumar, S., J. Aaron, and K. Sokolov. "Directional conjugation of antibodies to nanoparticles for synthesis of multiplexed optical contrast agents with both delivery and targeting moieties." Nature protocols 3.2 (2008): 314-320.

For Research Use Only.



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