Stem Cell-derived Exosomes and Therapeutic Applications
SC-Exo (Stem cell exosomes), as non-cellular substances, can be released from SCs. SC-Exo act independently of specific structural and functional organelles and are derived from conditioned cultures without SCs. This gives them the benefits of not being easily recognized and processed by the immune system, being non-immunogenic, and being transferable in different body fluids. Creative Biolabs has accumulated insights on different forms including native and engineered modified SC-Exo and their applications and provides one-stop customized research services.
Exosomes produced by various types of SCs in natural culture are referred to as native SC-Exo. After undergoing particular growing conditions, SCs can access exosomes in the extracellular environment. Bioactive chemicals found in these exosomes may have significant effects on neighboring cells and organs.
Fig. 1 Sources of native SC-Exo. (Thej & Kishore, 2021)
Fig. 2 Therapeutic potential of engineered SC-Exo. (Hur, 2020)
Creative Biolabs provides services for isolation, characterization, profiling, and functional probing of different forms of SC-Exo. Please contact us to learn more.
References
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Thej. C.; Kishore, R. Unfathomed nanomessages to the heart: translational implications of stem cell-derived, progenitor cell exosomes in cardiac repair and regeneration. Cells. 2021, 10(7): 1811.
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Hur, Y.H.; et al. Extracellular vesicles and their roles in stem cell biology. Stem Cells. 2020, 38(4): 469-476.
For Research Use Only. Cannot be used by patients.
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