Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
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HighlightsMelanin-concentrating hormone (MCH) receptors form a small part of GPCRs family, which can bind MCH, a 19-amino acid peptide encoded within a 165-amino acid preprohormone in mammalian. The distribution of MCH is general from fishes to mammals and it is not linked to pigmentation but seems to be essential in appetite regulation and obesity. Later on, a variety of physiologic processes mediated within the central nervous system (CNS), including energy homeostasis sleep and arousal, and emotionality are confirmed to be associated with MCH. Two MCH receptors (MCHR) have recently been characterized as MCHR1 and MCHR2, sharing approximately 38% homology. MCHR1 is expressed in all mammals, while MCHR2 is only found in some primates and carnivores including dogs, ferret, and humans. In higher species, the highest expressions of MCHR1 and MCHR2 are detected in the brain: frontal cortex, amygdala and nucleus accumbens, but also in the arcuate nucleus and in the ventral medial hypothalamus. These receptors are also moderately expressed in peripheral organs. The molecular pharmacology of MCHR1 and MCHR2 suggests that homologous antagonists might be useful in the treatment of obesity, anxiety and depression.
Here show two members of MCHRs: MCHR1 and MCHR2. MCHR2 displays a 10-fold less potent affinity for MCH than MCHR1. MCHR1 activation leads to an increase in intracellular Ca2+ accumulation acting through the Gq-coupled pathway and/or reduction of cyclic adenosine monophosphate (cAMP) levels via the Gi/o-coupled pathway. While the signal transduction mechanism of MCHR2 is limited to the Gq-mediated increase in intracellular Ca2+ levels.
Aided by cutting-edge Magic™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, stable cell line.
Meanwhile, our Magic™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
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