Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsNADPH oxidases (NOXs) are the membrane-binding enzyme complexes found in the membrane of intracellular organelles. It is known as a primary source of ROS. NOXs can catalyze electron donor NADPH or NADH and transfer electrons to molecular oxygen leading to superoxide anion production. The electron transfer system in NOX is composed of the C-terminal cytoplasmic region, and the N-terminal six-transmembrane domains containing two hemes, a structure similar to that of cytochrome b of the mitochondrial bc1 complex. NOXs are responsible for killing the intracellular pathogens through promoting the production of superoxide in phagocytic cells. Besides, NOXs present in the vascular wall is associated with vascular diseases such as Ang II-induced hypertension, diabetes mellitus, and atherosclerosis. It is reported that ROS produced by NOXs can activate an enzyme that promotes the macrophages containing cholesterol adhere to the artery wall leading to atherosclerosis. While NOX inhibitors can reverse atherosclerosis.
NOX contains several isoforms including NOX1-5, NOX oxidase 1 and 2, NOX organizer 1, and NOX activator 1. Here is part of NOXs in humans including NOX1, NOX4, and NOX5. NOX4 is most associated with idiopathic pulmonary fibrosis (IPF) and highly expressed in pulmonary fibroblasts of patients with IPF. NOX5 is not only as an electron transferring enzyme but also a calcium-dependent proton channel.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
