Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCalcium ions have important roles in a variety of cellular processes, including intracellular signaling, protein folding, enzyme activation, and initiation of programmed cell death. Stromal interaction molecule (STIM) proteins are critical components in coordinating calcium release and entry signals and in maintaining cellular calcium homeostasis. As calcium sensors in the interior of the endoplasmic reticulum (ER), STIM proteins are activated by changes of ER calcium levels and then rapidly translocate into junctions formed between the ER and the plasma membrane, where they interact with plasma membrane ORAI channels to mediate finely controlled calcium ion signals and to homeostatically balance cellular calcium ions. New studies reveal that, besides calcium ions, STIM proteins can respond to other cellular stressors, such as oxidative and hypoxic conditions, temperature fluctuation, and changes in pH. Moreover, these proteins are also involved in some tissue-specific functions, such as growth and development of different muscles.
Dysregulation of calcium flux has been reported in cancers, autoimmune diseases, and other diseases. Thus, STIM proteins are important therapeutic targets in diseases with dysregulated calcium flux. Here, we give an introduction that briefly summarizes the role of STIM proteins as stress sensors, the molecular mechanisms, and their implications in different diseases.
The isolation, purification, and reconstitution of functional transmembrane proteins are critical in their academic research and drug discovery. As an undisputed expert in this filed, Creative Biolabs has established our cutting-edge Magic™ membrane protein production platform, that provides the most comprehensive membrane protein preparations services by reconstituting your targets into formats such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. Thus, we can offer rapid, high-quality, and cost-effective membrane protein services to our esteemed clients.
Moreover, with full experience in antibody development and engineering, we can also offer discovery services of highly functional antibodies against these protein targets. Please see Magic™ Membrane Protein Antibody Discovery for more information. We also present DNA immunization service for anti-membrane protein antibody development. Contact us and experience the great value of our membrane protein-related services.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
