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Stromal Interaction Molecule Family

Calcium ions have important roles in a variety of cellular processes, including intracellular signaling, protein folding, enzyme activation, and initiation of programmed cell death. Stromal interaction molecule (STIM) proteins are critical components in coordinating calcium release and entry signals and in maintaining cellular calcium homeostasis. As calcium sensors in the interior of the endoplasmic reticulum (ER), STIM proteins are activated by changes of ER calcium levels and then rapidly translocate into junctions formed between the ER and the plasma membrane, where they interact with plasma membrane ORAI channels to mediate finely controlled calcium ion signals and to homeostatically balance cellular calcium ions. New studies reveal that, besides calcium ions, STIM proteins can respond to other cellular stressors, such as oxidative and hypoxic conditions, temperature fluctuation, and changes in pH. Moreover, these proteins are also involved in some tissue-specific functions, such as growth and development of different muscles.

Dysregulation of calcium flux has been reported in cancers, autoimmune diseases, and other diseases. Thus, STIM proteins are important therapeutic targets in diseases with dysregulated calcium flux. Here, we give an introduction that briefly summarizes the role of STIM proteins as stress sensors, the molecular mechanisms, and their implications in different diseases.

Human Stromal Interaction Molecule Members
STIM1 STIM2

The isolation, purification, and reconstitution of functional transmembrane proteins are critical in their academic research and drug discovery. As an undisputed expert in this filed, Creative Biolabs has established our cutting-edge Magic™ membrane protein production platform, that provides the most comprehensive membrane protein preparations services by reconstituting your targets into formats such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers. Thus, we can offer rapid, high-quality, and cost-effective membrane protein services to our esteemed clients.

Magic™ membrane protein production platform – Creative Biolabs

Moreover, with full experience in antibody development and engineering, we can also offer discovery services of highly functional antibodies against these protein targets. Please see Magic™ Membrane Protein Antibody Discovery for more information. We also present DNA immunization service for anti-membrane protein antibody development. Contact us and experience the great value of our membrane protein-related services.

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