Gut-Liver Two-Organs-on-a-Chip Model Introduction

The gut and liver are the organs that play a major role in drug absorption and metabolism following oral administration. The combination of cell cultures representing these tissues in a microphysiological system (MPS) format is therefore highly relevant. Here at Creative Biolabs, we present an integrated gut-liver-on-a-chip model as a simplified in vitro human model, which can help obtain deeper insights into the underlying mechanisms for the development of new drugs, treatments, and diagnostic tools.

Construction of Our Gut-Liver Two-organs-on-a-chip Model

Our gut-liver-on-a-chip model can both mono- and co-culture gut and liver cell types within the same format to elucidate inter-tissue interactions in which both intestinal and hepatic cells were simultaneously included on the chip. Our two-organs-on-a-chip model is made of PDMS with gas permeability, biocompatibility, and transparency and consists of perfusion and control layers. The perfusion layer had three sets of two cell culture chambers linked by microfluidic channels. The control layer had a thin and flexible PDMS membrane to integrate the microvalves and pump, which allowed robust open or close control with our previously reported microfabrication technology.

Fig 1. Fabrication procedure for the iGLC platform.¹

Advantages of Our Gut-Liver Two-organs-on-a-chip Model

Applications of Gut-Liver Two-organs-on-a-chip Model

Why Choose Us?

Although facing the difficulty that living organs cannot be connected and disconnected to make simplified multiple-hit-theory models, Creative Biolabs still manage to design our gut-liver two-organs-on-a-chip model to better recapitulate the micro-environment in vitro and investigate the mechanism of gut-liver progression. We will help you to open the possibility for future investigations of prodrugs where a combination of intestinal and hepatic processes determines drug and metabolite exposure. View our website for more organ-on-a-chip models.

• Heart-Liver Two-organ-on-a-chip Model
• Neuromuscular Junction Two-organ-on-a-chip Model
• Heart-Liver-Cancer Three-organ-on-a-chip Model
• Heart-Liver-Skeletal Muscle-Neuron Four-organ-on-a-chip Model
• Heart-Liver-Skin Three-organ-on-a-chip Model

Related Services

Complementing our extensive assortment of organ-on-a-chip models, we proudly introduce tailored 3D biology-based assays designed to enhance your preclinical research endeavors. Leading by a team of experts in the realm of 3D biology, we are enthusiastic about offering comprehensive insights into our solutions. If you have any unique requirements for our organs-on-a-chip models or express interest in exploring Creative Biolabs' suite of 3D biology services, please don't hesitate to initiate contact.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction