Neuromuscular Junction Two-Organ-on-a-Chip Model Introduction

Neuromuscular junction (NMJ) is an important functional model for dissecting disease mechanisms. Creative Biolabs has broken through the restriction by ethical concerns and confounding environmental factors and forwarded an in vitro NMJ two-organs-on-a-chip model. It will provide you with exciting opportunities for advancements in tissue engineering.

Features of Our Neuromuscular Junction (NMJ) Two-organs-on-a-chip Model

NMJs are comprised of two cell kinds developing in dissimilar microenvironments. Our progression of classified in vitro models that recreate NMJs in culture will allow the examination of therapeutics for recovering malfunctioning NMJs.

Advancement of Our Neuromuscular Junction (NMJ) Two-organs-on-a-chip Model

While 2D NMJ co-cultures are short-lived, our 3D model has been modified by extracellular matrix (ECM) coating or microfabrication techniques that can improve cell attachment, viability, and morphology. The success of NMJ formation 3D cultures can be assessed by visualizing synaptic organization or by functional connectivity. This can reveal important insights into dose responses, drug efficacy, and toxicity studies. In these cultures, muscle contractions can be monitored by measuring cantilever movement or pillar deflexion. We also have incorporated biocompatible conductive material that projects into the 3D tissue cultures to measure electrical activity.

Fig 1. Analysis of ALS disease mechanisms in microfluidic devices.¹

Applications of Neuromuscular Junction (NMJ) Two-organs-on-a-chip Model

Why Choose Us?

Creative Biolabs' NMJ two-organs-on-a-chip model faithfully mimics the isolated in vivo environment while also allowing the site of action studies for treatments for NMJ-related diseases. Our model will help you to streamline drug development studies, subsequently enhancing candidate drug selection for a wide variety of neuromuscular disorders. Visit our website for more information.

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Related Services

Our organ-on-a-chip models have been shown to mimic human pathophysiology and predict human preclinical responses to therapeutics better than animal models do. Thus, the healthy and diseased human organ chip models from our labs for toxicity and efficacy testing represents a major advantage over existing testing approaches that use inbred healthy animals. Feel free to contact us for more information.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction