Heart-Liver-Skeletal Muscle-Neuron Four-Organs-on-a-Chip Model Introduction

Creative Biolabs' heart-liver-skeletal muscle-neuron chip model combines four organ equivalents within a human-like metabolizing environment and aims at in vivo-like pharmacokinetics and pharmacodynamics. Our company provides you with a stable and powerful tool for cultivating tissues of various origins under stable extracellular conditions.

Our Heart-Liver-Skeletal Muscle-Neuron Four-organs-on-a-chip Model

We applied replica molding of polydimethylsiloxane (PDMS) to create a single 2 mm high PDMS layer containing the respective microfluidic channel system, which was permanently bonded to a glass microscope slide using low-pressure plasma oxidation. The PDMS layer consisted of two compartments for cultivating cells and three pump membranes. We also loaded additional multi-organ-on-a-chip with liver microtissues or neurospheres for comparison purposes.

Fig 1. Multi-OoC model comprising a microfluidic motherboard, an external peristaltic pump, and capillary connections.¹

Advantages of Our Heart-Liver-Skeletal Muscle-Neuron Four-organs-on-a-chip Model

Applications

The multi-organs-on-a-chip models have significant potential in the drug discovery process and development. The heart-liver-skeletal muscle-neuron four-organs-on-a-chip model of Creative Biolabs can be used to evaluate drug candidates at an early stage, enabling a high-content analysis of the mode of action of substances in a near-physiological cellular environment.

Why Choose Us?

Creative Biolabs' heart-liver-skeletal muscle-neuron four-organs-on-a-chip model comprises an on-chip micropump, which eliminates the need for external media reservoirs and enables the chip to run at very low medium volumes, allowing for cellular interaction. It will help you in further studies elucidating the mechanism regarding co-cultivation among these four-organs-on-a-chip. View for more organ-on-a-chip models.

• Heart-Liver Two-organ-on-a-chip Model
• Neuromuscular Junction Two-organ-on-a-chip Model
• Heart-Liver-Cancer Three-organ-on-a-chip Model
• Gut-Liver Two-organ-on-a-chip Model
• Heart-Liver-Skin Three-organ-on-a-chip Model

Related Services

As a global service provider in the field of life sciences, Creative Biolabs remains at the forefront of cutting-edge technologies, committed to delivering an array of reliable services as outlined below, tailored to meet the diverse research needs of our esteemed clients worldwide. If you are seeking further insights into our organs-on-a-chip models and the complementary assays in expediting your research initiatives, contact us for more information.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction