Heart-Liver-Cancer Three-Organs-on-a-Chip Model Introduction

Creative Biolabs' heart-liver-cancer three-organs-on-a-chip model recapitulates complex biochemical and biophysical factors of the tumor microenvironment in vivo. Our model possesses predictive ability by having systemic nature of heart-liver-cancer and provides a more reliable and predictable screening platform to precisely recapitulate the human tumor model, and thereby would be able to help you to further understand the complex nature of cancer and the effects of anticancer therapeutics in humans to develop effective therapeutic anticancer agents.

Features of Heart-Liver-Cancer Three-organs-on-a-chip Model

We have developed a novel heart-liver-cancer three-organs-on-a-chip model to mimic the body's response using interconnected compartments that represent various tissues or organs, which can be used to evaluate drug mixtures for potential efficacy in treating multidrug-resistant cancers. Our three-organs-on-a-chip model exploited integrated heart-liver microphysiological systems with functionally connected liver and cardiac microtissues derived from a single line of human pluripotent stem cells for drug testing in human health and disease.

Fig 1. Schematic of the tumor-on-a-chip platform for modeling tumor cell tissue structure and functional units in vitro.¹

Our proposed in vitro model to recapitulate the side effects of DXR using two types of cells: a liver cancer cell line (HepG2) and primary human cardiomyocytes (hCM). In the co-culture system, a drug metabolite might be released from HepG2 cells by metabolic activity, and reach hCM cells, thereby causing cell damage.

Fig 2. In vitro model mimics DXR side effects using HepG2 cells and hCMs.²

Advantages of Our Heart-Liver-Cancer Three-organs-on-a-chip Model

Applications of Heart-Liver-Cancer Three-organs-on-a-chip Model

Why Choose Us?

Creative Biolabs' heart-liver-cancer three-organs-on-a-chip model is a promising platform to facilitate the development of heart-liver cancer therapies. Our interdisciplinary cooperation among researchers from material science, biomedical engineering, cell biology, biophysics, and oncology make concerted efforts in designing and optimizing heart-liver-cancer three-organs-on-a-chip model for cancer research and drug discovery, finally translating bio-inspired designs to various applications. Visit our website for more information.

• Heart-Liver Two-organ-on-a-chip Model
• Neuromuscular Junction Two-organ-on-a-chip Model
• Heart-Liver-Skeletal Muscle-Neuron Four-organ-on-a-chip Model
• Gut-Liver Two-organ-on-a-chip Model
• Heart-Liver-Skin Three-organ-on-a-chip Model

Related Services

Our organ-on-a-chip models possess the ability to estimate both efficacy and toxicity for humans in preclinical trials, which is a huge advantage in allowing our clients to choose candidates that have a higher chance of becoming approved drugs. The chip models of Creative Biolabs can also be used throughout preclinical trials and coupling organ-on-a-chip models with physiologically based pharmacokinetic (PK) or pharmacodynamic (PD) models, who offer a rational basis to guide this process. Contact us for your advanced organ-on-a-chip models.

Related Sections:

• Single Organ-on-a-Chip Model Introduction
• Multiple Organs-on-a-Chip Model Introduction
• Barrier Tissue On-a-Chip Model Introduction
• Customized Tissue-on-a-Chip Model Introduction
• Disease-on-a-Chip Model Introduction