Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe 5-HT3 receptors are the only serotonergic receptors belonging to ligand-gated ion channel superfamily. Particularly, these membrane-spanning ‘cationotropic’ receptors belong to a pentameric neurotransmitter-gated Cys-loop receptor class and are responsible for fast excitatory and inhibitory neurotransmission. Until now, five subtypes of 5HT3Rs have been identified in humans; HTR3A, a homopentameric type and HTR3B, a heteropentameric form, and HTR3D, HTR3E, HTR3F that are yet to be elucidated. It is reported that 5-HT3Rs are widely distributed in different regions of the brain in rodents, primates, and humans, in particular, those that regulate affective behavior. Studies have shown that ionotropic 5HT3Rs could mediate fast neuronal transmission and subsequent neuromodulation in discrete brain areas. Stimulation of 5HT3Rs results in channel opening and the influx of cations into the cell, leading to rapid membrane depolarization and release of neurotransmitters. What’s more, several studies have reported that antagonism of 5HT3Rs produces antidepressant-like effects, indicating 5HT3Rs may act as a potential target for antidepressants
Here, we give a comprehensive introduction of members of the 5-HT3 receptor family, such as 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 3B, and 5-hydroxytryptamine receptor 3C. To learn more detailed information, please click the links below.
Aided by our advanced MemDX™ membrane protein production platform, Creative Biolabs is confident in offering diverse target membrane protein products in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches such as hybridoma technology, phage display technology. We also present DNA immunization service for anti-membrane protein antibody development. To get more detailed information, please feel free to contact us.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
