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HighlightsIntroduction of 5-HTR3E
5-HTR3E is encoded by 5-HTR3E gene. It is one of 5-HTR3 receptor subunits. 5-HTR3 receptor is composed of five 5-HTR3A receptor subunits forming homomeric receptors or at least 5-HTR3A receptor subunit in combination with one or more of the 5-HTR3B, 5-HTR3C, 5-HTR3D and 5-HTR3E receptor subunits forming complex heteromers. Each subunit contains an extracellular N-terminal and C-terminal domain, a transmembrane domain comprised of four alpha helices (M1-M4), and a large cytoplasmic domain.
| Basic Information of 5-HTR3E | |
| Protein Name | 5-hydroxytryptamine receptor 3E |
| Gene Name | 5-HTR3E |
| Aliases | 5-HT3E, 5-HT3-E, 5-HT3c1 |
| Organism | Homo sapiens (Human) |
| UniProt ID | A5X5Y0 |
| Transmembrane Times | 4 |
| Length (aa) | 482 |
| Sequence | MLAFILSRATPRPALGPLSYREHRVALLHLTHSMSTTGRGVTFTINCSGFGQHGADPTALNSVFNRKPFRPVTNISVPTQVNISFAMSAILDVVWDNPFISWNPEECEGITKMSMAAKNLWLPDIFIIELCVSRAGQREVPSPGSHRDHSLPLGPLMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLYTVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIVFYVAIRRRPSLYVINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLPTSGTPLIGVYFALCLSLMVGSLLETIFITHLLHVATTQPPPLPRWLHSLLLHCNSPGRCCPTAPQKENKGPGLTPTHLPGVKEPEVSAGQMPGPAEAELTGGSEWTRAQREHEAQKQHSVELWLQFSHAMDAMLFRLYLLFMASSIITVICLWNT |
Function of 5-HTR3E Membrane Protein
5-HTR3E, a 5-HTR3 receptor subunit, plays a very important role in neurotransmission involved many physiological functions. 5-HTR3 receptor is widely expressed in the central and peripheral nervous systems. It is a ligand-gated ion channel which mediates Na+, K+, and Ca2+ permeability. Activated 5-HTR3 receptors by binding 5-HTR mediate neuronal excitation and depolarization through regulating inward current. It has been revealed that the stimulation of 5-HTR3 receptors could affect the cardiovascular function, expand blood vessel and disturb respiration. Moreover, the activated 5-HTR3 receptors in CNS lead to mental disorder, anxiety, cognitive disorder, the reward and withdrawal effect from drugs of abuse and eating disorders. Hence 5-HTR3 antagonists are promising therapeutic agents for psychosis, anxiety disorder, impaired cognitive and learning ability, as well as alcohol and certain drugs of abuse. 5-HTR3 receptor antagonists have been identified to reduce alcohol consumption. And 5-HTR3 receptor antagonists can also apply to decrease nausea and emesis in cancer patients accepting chemotherapy.
Fig.1 The mouse 5-HTR3 receptor as determined by X-ray crystallography.
Application of 5-HTR3E Membrane Protein in Literature
The study shows that the simple or complex heteromeric 5-HT3 receptors assembled by C and E subunits may change the action of 5-HT and clinically used antagonists, such as ondansetron and palonosetron.
The study identifies that 5-HT3 antagonism controls impulsive choice through reducing discounting rates without affecting sensitivity to reinforcer magnitude in mice.
The review summarizes the 5-HT1A and 5-HT3 receptors can act as the potential targets for reducing seizure induced recurrent hypersynchronous neuronal activity and neurodegeneration.
The study shows that the higher dosage cisplatin and 5-HT3 receptor antagonist ondansetron combined with cisplatin possibly enhance the incidence of nephrotoxicity. However, 5-HT3 receptor antagonist tropisetron have a relatively moderate effect on kidney function, which indicates tropisetron can be a preferable alternative in the process of cisplatin chemotherapy.
The study shows that 5-HT3 receptor antagonism combined with selective serotonin reuptake inhibitor (SSRI) citalopram could increase antidepressant activity.
5-HTR3E Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-5-HTR3E antibody development services.
As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
