Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsATP-binding cassette subfamily G (ABCG family) is a class of transport proteins that consist of a single ABC cassette in the amino-terminal followed by six putative transmembrane domains. There are five members: ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. To become functionally active, ABCG1, ABCG2, and ABCG4 form homodimers, and ABCG5 and ABCG8 form obligate heterodimers. They function as cholesterol transporters except for ABCG2. ABCG1 and ABCG4 are involved in the reverse cholesterol transport from macrophage to the liver and ABCG5 as well as ABCG8 regulate the biliary excretion of cholesterol. Although ABCG2 is not involved in the cholesterol transporters, it plays an essential role in the pharmacokinetics of drugs in the clearance organs and tissue barriers due to its broad substrate specificity to xenobiotic compounds.
The five members of the ABCG family is encoded by different genes, ABCG1, ABCG2, ABCG4, ABCG5 and ABCG8 respectively. Except for ABCG5, and ABCG8 (2p21), other members genes of ABCG family are located in different sites of the chromosome (ABCG1: 21q22.3; ABCG2: 4q22.1; ABCG4: 11q23.3). Hence, the five members of ABCG family present some differences in expression pattern and functions. The following table shows five members of ABCG family.
Aided by cutting-edge MemDX™ membrane protein production platform, Creative Biolabs is proud to offer the preparation of these targets in required formats using various strategies, such as detergent micelles, proteoliposomes, nanodiscs, MP-VLPs, polymers, stable cell line.
Meanwhile, our MemDX™ membrane protein antibody discovery platform can help to discover antibodies against these targets, even fully humanized antibodies, by various approaches including hybridoma technology, phage display technology, etc. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
