Fmoc-N-amido-PEG12-acid PEGylation Crosslinker (CAT#: OLY-1023-YS75)

Description

This is a heterobifunctional, hydrophilic PEGylation linker commonly used as a building block in solid-phase peptide synthesis (SPPS). It features a terminal carboxylic acid and a base-labile Fmoc-protected amine. The carboxylic acid can be activated (e.g., with HBTU or EDC/NHS) to couple with primary amines. The Fmoc group provides robust orthogonal protection, stable to coupling conditions but easily removed with mild base (e.g., piperidine) to expose a new primary amine. The long, 12-unit PEG spacer significantly enhances hydrophilicity and provides a substantial, flexible spacer arm.

Molecular Weight

839.97

Purity

>95.0%

Formula

C₄₂H₆₅NO₁₆

Product Type

Heterobifunctional Crosslinkers ; PEGylation Reagents

Group 1

Other

Group 2

COOH

Form (20 deg.C)

Liquid

Storage Condition

Store under inert gas, -20°C

Molecular Structure