Cas No.: 39028-27-8
PRODUCT INFORMATION
Description
SIA is a classic heterobifunctional, non-cleavable crosslinker. It features an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive iodoacetyl group. The NHS ester reacts efficiently with primary amines (lysines) at pH 7.0-9.0. The iodoacetyl group is an alkylating agent that reacts specifically with thiols (cysteines) at pH 7.5-8.5 to form a highly stable, irreversible thioether bond. While it reacts slower than a maleimide, the iodoacetyl group is less prone to hydrolysis. It is used for short-range, stable crosslinking of amines to thiols.
Molecular Weight
283.02
Purity
>95.0%
Formula
C₆H₆INO₄
Product Type
Heterobifunctional Crosslinkers
Group 1
NHS
Group 2
X (F, Cl, Br, I)
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
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