Cas No.: 39028-27-8
PRODUCT INFORMATION
Description
SIA is a classic heterobifunctional, non-cleavable crosslinker. It features an amine-reactive N-hydroxysuccinimide (NHS) ester and a sulfhydryl-reactive iodoacetyl group. The NHS ester reacts efficiently with primary amines (lysines) at pH 7.0-9.0. The iodoacetyl group is an alkylating agent that reacts specifically with thiols (cysteines) at pH 7.5-8.5 to form a highly stable, irreversible thioether bond. While it reacts slower than a maleimide, the iodoacetyl group is less prone to hydrolysis. It is used for short-range, stable crosslinking of amines to thiols.
Molecular Weight
283.02
Purity
>95.0%
Formula
C₆H₆INO₄
Product Type
Heterobifunctional Crosslinkers
Group 1
NHS
Group 2
X (F, Cl, Br, I)
Form (20 deg.C)
Solid
Storage Condition
Store under inert gas, <0°C
Molecular Structure
For Research Use Only | Not For Clinical Use
Related products
- Fmoc-N-amido-PEG2-acid PEGylation Crosslinker (CAT#: OLY-1023-YS265)
- Alloc-Val-Cit-PAB-OH Enzyme Cleavable Linker for ADC (CAT#: OLY-1023-YS271)
- m-PEG12-NHS Ester PEGylation Crosslinker (CAT#: OLY-1023-YS253)
- Azide-PEG8-alcohol (CAT#: OLY-1023-YS95)
- 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium Chloride (CAT#: OLY-1023-YS292)
- Azido-PEG4-NHS Ester (CAT#: OLY-1023-YS100)
- Fmoc-8-amino-3,6-dioxaoctanoic Acid PEGylation Crosslinker (CAT#: OLY-1023-YS45)
- 4-[3-(Trifluoromethyl)-3H-diazirin-3-yl]benzyl Bromide Photo-reactive Crosslinker (CAT#: OLY-1023-YS87)
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.