Home > Products > CD2 & TCR (Vβ8) > Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-Fc)

Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-Fc)  (FABVC-H225)

Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-CD2 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-TCR (Vβ8) to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can activate T cells. It is designed for the research of Tumors therapy.

Specifications
Targets
CD2 & TCR (Vβ8)
Type
Fab-Fc Fusion Proteins
Species Reactivity
Mouse
Target 1
CD2
Host Animal 1
Human
Target 2
TCR (Vβ8)
Host Animal 2
Human
Application
FuncS; Promising therapeutic agent
Related Disease
Tumors
Targets
Target 1
CD2
Gene ID
UniProt ID
Alternative Names
CD2; CD2 molecule; T11; SRBC; LFA-2; T-cell surface antigen CD2; leukocyte function-associated antigen-2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor
Target 2
TCR (Vβ8)
Gene ID
Alternative Names
Trbv8; T cell receptor beta variable 8; TCR; T-cell receptor

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