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M2 & TCR (Vβ8) Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem Diabody) Human Tandem Diabody M2 Mouse TCR (Vβ8) Mouse Inquiry
SCIGG-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scIgG) Human Single chain IgGs M2 Mouse TCR (Vβ8) Mouse Inquiry
FVTIG-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv4-Ig) Human scFv4-Ig M2 Mouse TCR (Vβ8) Mouse Inquiry
BSSG-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-IgG) Human scFv-IgG M2 Mouse TCR (Vβ8) Mouse Inquiry
IGLFV-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv M2 Mouse TCR (Vβ8) Mouse Inquiry
BSGV-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-Fv) Human IgG-Fv M2 Mouse TCR (Vβ8) Mouse Inquiry
BSDG-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Fv-IgG) Human Fv-IgG M2 Mouse TCR (Vβ8) Mouse Inquiry
BABFV-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 M2 Mouse TCR (Vβ8) Mouse Inquiry
FABVC-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc M2 Mouse TCR (Vβ8) Mouse Inquiry
SCDBC-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 M2 Mouse TCR (Vβ8) Mouse Inquiry
BSDBC-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 M2 Mouse TCR (Vβ8) Mouse Inquiry
SCDBF-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc M2 Mouse TCR (Vβ8) Mouse Inquiry
BSFVF-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc M2 Mouse TCR (Vβ8) Mouse Inquiry
BSDBF-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Diabody-Fc) Human Diabody-Fc M2 Mouse TCR (Vβ8) Mouse Inquiry
BSTF-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv M2 Mouse TCR (Vβ8) Mouse Inquiry
BSCFV-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-Fc) Human scFv-Fc M2 Mouse TCR (Vβ8) Mouse Inquiry
MNAB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Miniantibody) Human Miniantibody M2 Mouse TCR (Vβ8) Mouse Inquiry
BSFC-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-CH3) Human scFv-CH3 M2 Mouse TCR (Vβ8) Mouse Inquiry
BSCC-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL M2 Mouse TCR (Vβ8) Mouse Inquiry
BIBD-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Bibody) Human Bibody M2 Mouse TCR (Vβ8) Mouse Inquiry
FABFV-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-Fv) Human Fab-Fv M2 Mouse TCR (Vβ8) Mouse Inquiry
MiniB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Minibody) Human Minibody M2 Mouse TCR (Vβ8) Mouse Inquiry
SCDB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody M2 Mouse TCR (Vβ8) Mouse Inquiry
FABIG-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-IgG) Human Fab-IgG M2 Mouse TCR (Vβ8) Mouse Inquiry
TRIB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv M2 Mouse TCR (Vβ8) Mouse Inquiry
BSIG-180 Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-IgG) Human IgG-IgG M2 Mouse TCR (Vβ8) Mouse Inquiry
CROSSAB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (CrossMab) Human CrossMab M2 Mouse TCR (Vβ8) Mouse Inquiry
IGFV-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-scFv) Human IgG-scFv M2 Mouse TCR (Vβ8) Mouse Inquiry
BSDB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Diabody) Human Diabody M2 Mouse TCR (Vβ8) Mouse Inquiry
BSFAB-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem Fab) Human Tandem Fab M2 Mouse TCR (Vβ8) Mouse Inquiry
BSFV-180 Recombinant Anti-M2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem scFv) Human Tandem scFv M2 Mouse TCR (Vβ8) Mouse Inquiry
T-BSDB-H223 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Tandem Diabody) Mouse Tandem Diabody CD2 Human TCR (Vβ8) Human Inquiry
T-BSDB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem Diabody) Mouse Tandem Diabody CD2 Mouse TCR (Vβ8) Mouse Inquiry
SCIGG-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scIgG) Mouse Single chain IgGs CD2 Human TCR (Vβ8) Human Inquiry
SCIGG-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scIgG) Mouse Single chain IgGs CD2 Mouse TCR (Vβ8) Mouse Inquiry
FVTIG-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scFv4-Ig) Mouse scFv4-Ig CD2 Human TCR (Vβ8) Human Inquiry
FVTIG-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv4-Ig) Mouse scFv4-Ig CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSSG-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scFv-IgG) Mouse scFv-IgG CD2 Human TCR (Vβ8) Human Inquiry
BSSG-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-IgG) Mouse scFv-IgG CD2 Mouse TCR (Vβ8) Mouse Inquiry
IGLFV-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (IgG(L)-scFv) Mouse IgG-scFv CD2 Human TCR (Vβ8) Human Inquiry
IGLFV-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG(L)-scFv) Mouse IgG-scFv CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSGV-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (IgG-Fv) Mouse IgG-Fv CD2 Human TCR (Vβ8) Human Inquiry
BSGV-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-Fv) Mouse IgG-Fv CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSDG-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Fv-IgG) Mouse Fv-IgG CD2 Human TCR (Vβ8) Human Inquiry
BSDG-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fv-IgG) Mouse Fv-IgG CD2 Mouse TCR (Vβ8) Mouse Inquiry
BABFV-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (F(ab')2-scFv2) Mouse F(ab')2-scFv2 CD2 Human TCR (Vβ8) Human Inquiry
BABFV-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (F(ab')2-scFv2) Mouse F(ab')2-scFv2 CD2 Mouse TCR (Vβ8) Mouse Inquiry
FABVC-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-Fc) Mouse Fab-scFv/sdAb-Fc CD2 Human TCR (Vβ8) Human Inquiry
FABVC-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-Fc) Mouse Fab-scFv/sdAb-Fc CD2 Mouse TCR (Vβ8) Mouse Inquiry
SCDBC-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scDiabody-CH3) Mouse scDiabody-CH3 CD2 Human TCR (Vβ8) Human Inquiry
SCDBC-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scDiabody-CH3) Mouse scDiabody-CH3 CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSDBC-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Diabody-CH3) Mouse Diabody-CH3 CD2 Human TCR (Vβ8) Human Inquiry
BSDBC-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Diabody-CH3) Mouse Diabody-CH3 CD2 Mouse TCR (Vβ8) Mouse Inquiry
SCDBF-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scDiabody-Fc) Mouse scDiabody-Fc CD2 Human TCR (Vβ8) Human Inquiry
SCDBF-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scDiabody-Fc) Mouse scDiabody-Fc CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSFVF-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Tandem scFv-Fc) Mouse Tandem scFv-Fc CD2 Human TCR (Vβ8) Human Inquiry
BSFVF-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem scFv-Fc) Mouse Tandem scFv-Fc CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSDBF-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Diabody-Fc) Mouse Diabody-Fc CD2 Human TCR (Vβ8) Human Inquiry
BSDBF-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Diabody-Fc) Mouse Diabody-Fc CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSTF-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scFv-Fc-scFv) Mouse scFv-Fc-scFv CD2 Human TCR (Vβ8) Human Inquiry
BSTF-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-Fc-scFv) Mouse scFv-Fc-scFv CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSCFV-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scFv-Fc) Mouse scFv-Fc CD2 Human TCR (Vβ8) Human Inquiry
BSCFV-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-Fc) Mouse scFv-Fc CD2 Mouse TCR (Vβ8) Mouse Inquiry
MNAB-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Miniantibody) Mouse Miniantibody CD2 Human TCR (Vβ8) Human Inquiry
MNAB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Miniantibody) Mouse Miniantibody CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSFC-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scFv-CH3) Mouse scFv-CH3 CD2 Human TCR (Vβ8) Human Inquiry
BSFC-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-CH3) Mouse scFv-CH3 CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSCC-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (scFv-CH1/CL) Mouse scFv-CH1/CL CD2 Human TCR (Vβ8) Human Inquiry
BSCC-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (scFv-CH1/CL) Mouse scFv-CH1/CL CD2 Mouse TCR (Vβ8) Mouse Inquiry
BIBD-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Bibody) Mouse Bibody CD2 Human TCR (Vβ8) Human Inquiry
BIBD-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Bibody) Mouse Bibody CD2 Mouse TCR (Vβ8) Mouse Inquiry
FABFV-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Fab-Fv) Mouse Fab-Fv CD2 Human TCR (Vβ8) Human Inquiry
FABFV-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-Fv) Mouse Fab-Fv CD2 Mouse TCR (Vβ8) Mouse Inquiry
MiniB-H225 Recombinant Human Anti-CD2 x Human Anti-TCR (Vβ8) Bispecific Antibody (Minibody) Mouse Minibody CD2 Human TCR (Vβ8) Human Inquiry
MiniB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Minibody) Mouse Minibody CD2 Mouse TCR (Vβ8) Mouse Inquiry
SCDB-H223 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Single-chain Diabody) Mouse Single-chain Diabody CD2 Human TCR (Vβ8) Human Inquiry
FABIG-H223 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-IgG) Mouse Fab-IgG CD2 Human TCR (Vβ8) Human Inquiry
TRIB-H225 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-scFv) Mouse Fab-scFv-scFv CD2 Human TCR (Vβ8) Human Inquiry
BSIG-H223 Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-IgG) Mouse IgG-IgG CD2 Human TCR (Vβ8) Human Inquiry
CROSSAB-H223 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (CrossMab) Mouse CrossMab CD2 Human TCR (Vβ8) Human Inquiry
IGFV-H223 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-scFv) Mouse IgG-scFv CD2 Human TCR (Vβ8) Human Inquiry
BSDB-H223 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Diabody) Mouse Diabody CD2 Human TCR (Vβ8) Human Inquiry
BSFAB-H223 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem Fab) Mouse Tandem Fab CD2 Human TCR (Vβ8) Human Inquiry
BSFV-H223 Recombinant Human Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem scFv) Mouse Tandem scFv CD2 Mouse TCR (Vβ8) Mouse Inquiry
SCTB-023 Recombinant Anti-TCR (Vβ8) x Anti-CD2 Bispecific Antibody (Single-chain Triplebody) Mouse Single-chain Triplebody CD2 Mouse TCR (Vβ8) Mouse Inquiry
SCDB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Single-chain Diabody) Mouse Single-chain Diabody CD2 Mouse TCR (Vβ8) Mouse Inquiry
FABIG-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-IgG) Mouse Fab-IgG CD2 Mouse TCR (Vβ8) Mouse Inquiry
TRIB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Fab-scFv-scFv) Mouse Fab-scFv-scFv CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSIG-048 Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-IgG) Mouse IgG-IgG CD2 Mouse TCR (Vβ8) Mouse Inquiry
CROSSAB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (CrossMab) Mouse CrossMab CD2 Mouse TCR (Vβ8) Mouse Inquiry
IGFV-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (IgG-scFv) Mouse IgG-scFv CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSDB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Diabody) Mouse Diabody CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSFAB-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem Fab) Mouse Tandem Fab CD2 Mouse TCR (Vβ8) Mouse Inquiry
BSFV-048 Recombinant Anti-CD2 x Anti-TCR (Vβ8) Bispecific Antibody (Tandem scFv) Mouse Tandem scFv CD2 Mouse TCR (Vβ8) Mouse Inquiry

Background

The influenza virus M2 protein, possessing ion channel activity, forms diminutive proton channels in the viral envelope, responsible for mediating the entry of ions into the viral particle during its uncoating phase. The M2 protein's most recognized function is to regulate the pH of the viral membrane during cell entry and adjust the pH of the host cell's Golgi apparatus membrane in the virus maturation process. The M2 protein is a pivotal protein for viral replication and has been considered as a potential target for anti-influenza drugs in multiple studies.

The T-cell surface receptor, constituted by alpha and beta peptide chains—the latter which includes a variant identified as Vβ8—is implicated in the proliferation, activation, and cytokine release in T-cells. A bispecific antibody binding to both Vβ8 and the M2 protein has been developed and proposed as a potential effective intervention for influenza virus infection.

Structure of influenza viral particles and membrane proteins. (Pielak, et al., 2011) Fig.1 Viral particle of influenza and membrane proteins.1

Reference

  1. Pielak, Chou, et al. " Influenza M2 proton channels." Biochim Biophys Acta. 1808.2 (2011): 522-529.
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