Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-scFv-Fc) (FABVC-191)

Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-scFv-Fc) requires expression of three polypeptide chains, encoding two heavy chains (Fc-containing chains) and one light chain, respectively. The Fab of anti-VEGFR2 antibody variable domain is fused to the Fc-knob domain with a hinge region and the same as the scFv of anti-VEGFR3 to the Fc-hole domain, or vice versa. The Fab-Fc and scFv-Fc fragments can be paired via the interaction of the Fc regions. This BsAb can block two receptors simultaneously. It is designed for the research of Cancers therapy.

Datasheet INQUIRY

Specifications

Targets

VEGFR2 & VEGFR3

Type

Fab-Fc Fusion Proteins

Species Reactivity

Human

Application

FuncS; Promising therapeutic agent

Related Disease

Cancers

Targets

Target 1

VEGFR2

Gene ID

3791

UniProt ID

A0A024RD88

Alternative Names

FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR

Target 2

VEGFR3

Gene ID

2324

UniProt ID

P35916

Alternative Names

FLT4; PCL; FLT-4; FLT41; LMPH1A; VEGFR3; VEGFR-3; fms related tyrosine kinase 4; Vascular endothelial growth factor 3

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.

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Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (Fab-scFv-Fc) (CAT#: FABVC-191)

Specifications

Targets

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