Home > Products > VEGFR2 & VEGFR3 > Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin)

Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin)  (BSFAB-BGN018)

Recombinant Anti-VEGFR2 x Anti-VEGFR3 Tandem Fab-BGN immunotoxin (Bispecific Immunotoxin) is designed to be expressed as the Bouganin (BGN) fused to a tandem Fab recognizing VEGFR2 and VEGFR3. It contains three chains and a His-tag at the C/N terminus for affinity purification. The two Fd regions are connected by a flexible linker. This bispecific immunotoxin can deliver BGN to antigen-specific cells. Then BGN is a single chain, type I ribosone inactivating protein (RIP) and can kill the target cells. The bispecific immunotoxin is designed for the research of Cancers therapy.

Specifications

Targets
VEGFR2 & VEGFR3
Type
Bispecific Immunotoxin
Species Reactivity
Human
Target 1
VEGFR2
Host Animal 1
Mouse
Target 2
VEGFR3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Cancers

Targets

Target 1
VEGFR2
Gene ID
UniProt ID
Alternative Names
FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR
Target 2
VEGFR3
Gene ID
UniProt ID
Alternative Names
FLT4; PCL; FLT-4; FLT41; LMPH1A; VEGFR3; VEGFR-3; fms related tyrosine kinase 4; Vascular endothelial growth factor 3

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