Home > Products > VEGFR2 & VEGFR3 > Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-Fc-scFv)

Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-Fc-scFv)  (BSTF-191)

Recombinant Anti-VEGFR2 x Anti-VEGFR3 Bispecific Antibody (scFv-Fc-scFv) is designed to be expressed as one chain, then assembled to a homodimer of bivalent scFv fragments and the Fc region of IgG. The anti-VEGFR2 scFv is fused to the N-terminus of Fc via a hinge region while another anti-VEGFR3 scFv is linked to the C-terminus of Fc. This scFv-Fc-scFv format has 2+2 antigen-binding valency by employing different scFv fragments. This BsAb can block two receptors simultaneously. It is designed for the research of Cancers therapy.

Specifications

Targets
VEGFR2 & VEGFR3
Type
scFv-based Bispecific Fragments
Species Reactivity
Human
Target 1
VEGFR2
Host Animal 1
Mouse
Target 2
VEGFR3
Host Animal 2
Mouse
Application
FuncS; Promising therapeutic agent
Related Disease
Cancers

Targets

Target 1
VEGFR2
Gene ID
UniProt ID
Alternative Names
FLK1; CD309; VEGFR; VEGFR2; Vascular endothelial growth factor receptor 2; Kinase insert domain receptor; Fetal liver kinase 1; Kinase insert domain receptor, a type III receptor; KDR
Target 2
VEGFR3
Gene ID
UniProt ID
Alternative Names
FLT4; PCL; FLT-4; FLT41; LMPH1A; VEGFR3; VEGFR-3; fms related tyrosine kinase 4; Vascular endothelial growth factor 3

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