Lymphoma is reported the most common tumor of hematological malignancy cancer or blood cancer, in the developed countries. There are two major types of lymphoma that are Hodgkin's lymphoma and non-Hodgkin's lymphoma. Approximately 85% of non-Hodgkin's lymphomas from B cells, an essential part of the individual immunity. B-cell lymphoma usually arises in the lymph nodes or lymphoid tissues, including the blood, spleen, bone marrow, and so on. In order to establish a murine model for the monoclonal anti-idiotype therapy of B cell lymphomas, a group of different rat monoclonal anti-idiotype antibodies are generated against the surface immunoglobulin (Ig) of the murine B cell tumor 38C13. And xenogeneic antibodies are made of the fusion of rat spleen cell immunized with the 38C13 idiotype. ITGAL (integrin subunit alpha L), also referred to ITGB2 (Integrin subunit beta 2), CD18, MF17, LFA-1, or MAC-1, is a transmembrane cell surface protein expressed on all leukocytes. In humans, it is encoded by ITGB2 genes, which is located on the chromosome 21q22.3. CD18 belongs to a leukocyte integrin family of heterodimeric adhesion molecules which is composed of a unique alpha-subunit and a common beta-subunit. CD18 is able be encode an integrin beta chain combining with different alpha chains to form diverse integrin heterodimers. These heterodimeric complexes include integrin subunits alpha D, alpha L (complex also known as LFA‑1), alpha M (MAC-1), and alpha X (CR-4). They are essential in cell adhesion, leukocyte trafficking, and cell-surface mediated signaling.