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TLR1 Bispecific Antibodies
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CAT# Product Name Species Reactivity BsAb Type Target 1 Host Animal 1 Target 2 Host Animal 2 INQUIRY
T-BSDB-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (Tandem Diabody) Human Tandem Diabody malaria antigen Mouse TLR1 Mouse Inquiry
SCIGG-H345 Recombinant Human Anti-Malaria Antigen x Human Anti-TLR1 Bispecific Antibody (scIgG) Human Single chain IgGs Malaria Antigen Human TLR1 Human Inquiry
SCIGG-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (scIgG) Human Single chain IgGs Malaria Antigen Mouse TLR1 Mouse Inquiry
FVTIG-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig malaria antigen Human TLR1 Human Inquiry
FVTIG-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv4-Ig) Human scFv4-Ig malaria antigen Mouse TLR1 Mouse Inquiry
BSSG-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scFv-IgG) Human scFv-IgG malaria antigen Human TLR1 Human Inquiry
BSSG-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv-IgG) Human scFv-IgG malaria antigen Mouse TLR1 Mouse Inquiry
IGLFV-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv malaria antigen Human TLR1 Human Inquiry
IGLFV-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (IgG(L)-scFv) Human IgG-scFv malaria antigen Mouse TLR1 Mouse Inquiry
BSGV-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (IgG-Fv) Human IgG-Fv malaria antigen Mouse TLR1 Mouse Inquiry
BSGV-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (IgG-Fv) Human IgG-Fv malaria antigen Mouse TLR1 Mouse Inquiry
BSDG-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (Fv-IgG) Human Fv-IgG malaria antigen Human TLR1 Human Inquiry
BSDG-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (Fv-IgG) Human Fv-IgG malaria antigen Mouse TLR1 Mouse Inquiry
BABFV-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 malaria antigen Human TLR1 Human Inquiry
BABFV-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (F(ab')2-scFv2) Human F(ab')2-scFv2 malaria antigen Mouse TLR1 Mouse Inquiry
FABVC-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc malaria antigen Human TLR1 Human Inquiry
FABVC-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (Fab-scFv-Fc) Human Fab-scFv/sdAb-Fc malaria antigen Mouse TLR1 Mouse Inquiry
SCDBC-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 malaria antigen Human TLR1 Human Inquiry
SCDBC-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scDiabody-CH3) Human scDiabody-CH3 malaria antigen Mouse TLR1 Mouse Inquiry
BSDBC-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 malaria antigen Human TLR1 Human Inquiry
BSDBC-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (Diabody-CH3) Human Diabody-CH3 malaria antigen Mouse TLR1 Mouse Inquiry
SCDBF-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc malaria antigen Human TLR1 Human Inquiry
SCDBF-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scDiabody-Fc) Human scDiabody-Fc malaria antigen Mouse TLR1 Mouse Inquiry
BSFVF-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc malaria antigen Human TLR1 Human Inquiry
BSFVF-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (Tandem scFv-Fc) Human Tandem scFv-Fc malaria antigen Mouse TLR1 Mouse Inquiry
BSDBF-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc malaria antigen Human TLR1 Human Inquiry
BSDBF-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (Diabody-Fc) Human Diabody-Fc malaria antigen Mouse TLR1 Mouse Inquiry
BSTF-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv malaria antigen Mouse TLR1 Mouse Inquiry
BSTF-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv-Fc-scFv) Human scFv-Fc-scFv malaria antigen Mouse TLR1 Mouse Inquiry
BSCFV-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scFv-Fc) Human scFv-Fc malaria antigen Mouse TLR1 Mouse Inquiry
BSCFV-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv-Fc) Human scFv-Fc malaria antigen Mouse TLR1 Mouse Inquiry
MNAB-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (Miniantibody) Human Miniantibody malaria antigen Mouse TLR1 Mouse Inquiry
MNAB-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (Miniantibody) Human Miniantibody malaria antigen Mouse TLR1 Mouse Inquiry
BSFC-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 malaria antigen Mouse TLR1 Mouse Inquiry
BSFC-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv-CH3) Human scFv-CH3 malaria antigen Mouse TLR1 Mouse Inquiry
BSCC-H345 Recombinant Human Anti-malaria antigen x Human Anti-TLR1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL malaria antigen Mouse TLR1 Mouse Inquiry
BSCC-181 Recombinant Anti-malaria antigen x Anti-TLR1 Bispecific Antibody (scFv-CH1/CL) Human scFv-CH1/CL malaria antigen Mouse TLR1 Mouse Inquiry
BIBD-H345 Recombinant Human Anti-Malaria Antigen x Human Anti-TLR1 Bispecific Antibody (Bibody) Human Bibody Malaria Antigen Mouse TLR1 Mouse Inquiry
BIBD-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Bibody) Human Bibody Malaria Antigen Mouse TLR1 Mouse Inquiry
FABFV-H345 Recombinant Human Anti-Malaria Antigen x Human Anti-TLR1 Bispecific Antibody (Fab-Fv) Human Fab-Fv Malaria Antigen Human TLR1 Human Inquiry
FABFV-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Fab-Fv) Human Fab-Fv Malaria Antigen Mouse TLR1 Mouse Inquiry
MiniB-H345 Recombinant Human Anti-Malaria Antigen x Human Anti-TLR1 Bispecific Antibody (Minibody) Human Minibody Malaria Antigen Human TLR1 Human Inquiry
MiniB-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Minibody) Human Minibody Malaria Antigen Mouse TLR1 Mouse Inquiry
BSFV-H342 Recombinant Human Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Tandem scFv) Human Tandem scFv Malaria Antigen Human TLR1 Human Inquiry
SCDB-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Single-chain Diabody) Human Single-chain Diabody Malaria Antigen Mouse TLR1 Mouse Inquiry
FABIG-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Fab-IgG) Human Fab-IgG Malaria Antigen Mouse TLR1 Mouse Inquiry
TRIB-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Fab-scFv-scFv) Human Fab-scFv-scFv Malaria Antigen Mouse TLR1 Mouse Inquiry
BSIG-181 Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (IgG-IgG) Human IgG-IgG Malaria Antigen Mouse TLR1 Mouse Inquiry
CROSSAB-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (CrossMab) Human CrossMab Malaria Antigen Mouse TLR1 Mouse Inquiry
IGFV-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (IgG-scFv) Human IgG-scFv Malaria Antigen Mouse TLR1 Mouse Inquiry
BSDB-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Diabody) Human Diabody Malaria Antigen Mouse TLR1 Mouse Inquiry
BSFAB-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Tandem Fab) Human Tandem Fab Malaria Antigen Mouse TLR1 Mouse Inquiry
BSFV-181 Recombinant Anti-Malaria Antigen x Anti-TLR1 Bispecific Antibody (Tandem scFv) Human Tandem scFv Malaria Antigen Mouse TLR1 Mouse Inquiry

Background

Toll-like receptor 1 (TLR1) is a type I transmembrane protein, which has an extracellular domain, a transmembrane domain, and a cytoplasmic Toll homologous signaling domain. The requirement of TLR1 for cytoplasmic and transmembrane transport domains is unique for proper localization. TLRs play an important role in the innate immune response by recognizing components derived from various pathogens. They have a strong binding ability to LPS, participate in the production of inflammatory factors, and play an important role in the host immune response to bacterial infection. TLR1 is an important receptor involved in the migration and activation of DC in gut-associated lymphoid tissues. Stimulation of TLR1 during vaccination or infection can promote immunity, the production of pathogen-specific T cells, the production of antibodies, and the eventual clearance of bacteria. Alternatively, inhibition of TLR1 may suppress chronic inflammation by suppressing the generation of antigen-specific TH17 cells, which may provide a therapeutic approach for patients with mucosal autoimmune diseases or inflammatory bowel disease.

Fig.1 Signaling pathway of toll-like receptors (TLRs). (Isaza-Correa, 2014) Fig.1 Signaling pathway of toll-like receptors (TLRs).1

Reference

  1. Isaza-Correa, Johana M., et al. "Toll-like receptors in the pathogenesis of human B cell malignancies." Journal of hematology & oncology 7.1 (2014): 1-10.
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