Creative Biolabs is a world leader in the development of ELISA based kits and offers a wide range of assay kits for specific detection of disease-related proteins. Electrochemiluminescence (ECL) is a type of luminescence that occurs during electrochemical reactions in solutions. Methods based on enzyme labels have been developed for chemiluminescent immunoassays in Creative Biolabs. Our professional team is optimized to help you with high-quality and cost-effective testing service to make your project a success.

How does it work?

In electrochemiluminescence, electrochemically generated intermediates undergo a high degree of exergonic reaction to produce an electronically excited state and then emits light when relaxed to a lower energy level. This wavelength of emitted photons corresponds to the energy gap between these two states. ECL excitation can be caused by the high energy electron transfer (redox) reaction of the electro-generated material. This luminescent excitation is a form of chemiluminescence in which one/all of the reactants are electrochemically produced on the electrode.

ECL is typically observed during the application of potential to an electrochemical cell electrode in a solution of an aprotic organic solvent (ECL composition) containing a solution of a luminescent material (metal complex, polyaromatic hydrocarbon, nanoparticle, or quantum dot). In organic solvents, the oxidized and reduced forms of the luminescent material can be produced simultaneously on different electrodes, or on a single electrode by scanning the potential between oxidation and reduction. Excitation energy is obtained from the recombination of oxidized and reduced species.

The principle of Electrochemiluminescence. Fig.1 The principle of Electrochemiluminescence.

Advantages of Our Electrochemiluminescence Immunoassay (ECLIA) Platforms

Creative Biolabs has been devoted for the development of highly sensitive, more flexible, quantitative, and easy-to-use electrochemiluminescence immunoassays-based kits. ECL proved to be very useful in analytical applications as a highly sensitive and selective method. ECL provides a wider dynamic range, higher sensitivity, reduced matrix effects, and requires lower sample volumes, which allows for a broader assay.

  • Combines analytical advantages of chemiluminescent analysis (absence of background optical signal) with ease of reaction control by applying electrode potential.
  • Versatility, simplified optical setup compared with photoluminescence (PL).
  • Good temporal and spatial control compared with chemiluminescence (CL).
  • Can be detected from picomolar sensitivity to dynamic range of more than six orders of magnitude.

The importance of electrochemiluminescence techniques detection for bio-related applications has been well established. ECLIA is heavily used commercially for many clinical lab applications. To assist customers for specific detection of disease-related proteins, Creative Biolabs provides a variety of ELISA based assay kits. If you are interested in our chemiluminescent immunoassay based kits development, please feel free to contact us for more details.

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