Tumor-derived cell lines have long been used to discover the biologic processes in oncology, as well as screening platforms for discovering and evaluating the efficacy of anti-tumor therapeutics. Creative Biolabs operates by scientists equipped with extensive experience and professional knowledge in xenograft tumor models and can provide a wide array of human tumor cell lines for your anti-tumor drug discovery.
Cell Line Derived Tumor Xenograft (CDX) Mouse Models
As a vital step in the process of antineoplastic agent discovery, cell line derived tumor xenograft (CDX) models are widely used for preclinical test of drug efficacy, PK/PD correlation, and combination therapy. Human tumor cell line xenografts establish tumors when implanted in immunodeficient mouse. In this kind of model, it's feasible to investigate the efficacy of novel agents in inhibiting tumor growth and development as well as the mechanisms of action.
Although implanting human tumors directly into mice is gradually popular in anti-tumor drug discovery due to their accurate recapitulation of patient tumor features, CDX models are still proved practically to be an efficient method for in vivo study in terms of their excellent repeatability.
Fig. 1 H&E stained sections of two independent well-differentiated adenocarcinomas (CRC039 and CRC075) show that tumor architecture remains similar after 11 passages in NOD/SCID mice.1
Establishment of CDX Mouse Models
CDX models are based on a variety of tumor cell lines that are easy to grow in culture and rapidly form tumors after inoculation into immunodeficient mice. The cells may be implanted subcutaneously, intravenously or orthotopically to induce tumors in different microenvironments.
Following is the list of available commonly used human tumor cell lines at Creative Biolabs:
Advantages of CDX mouse models in Creative Biolabs
Why choose us?
Our broad set of xenograft cell lines ensure various assessing alternatives for your oncology agent discovery. At Creative Biolabs, a team of highly experienced scientists are focused on xenograft tumor models for the discovery novel anti-tumor agents. With professional knowledge and comprehensive capability, Creative Biolabs can support you to evaluate novel anti-tumor agents in a timely and cost-effective method. If you have any special needs in the establishment of cell line derived tumor xenograft (CDX) mouse models or be interested in learning more about Creative Biolabs' animal models or drug discovery service, please contact us for technical support.
Furthermore, you can choose other types of rodent tumor models in Creative Biolabs for your efficacy evaluation and pharmacology studies:
Reference
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