Xenograft models are integral in the process of anti-tumor drug discovery and provide critical decision-making information to ensure the advancement of a novel agent. Cooperating with Creative Biolabs provides you with the access to validated and well-characterized xenograft models. Our highly experienced preclinical team are ready to assist you establishing the most appropriate xenograft tumor model and screening method for your research on anti-tumor drug discovery.
Xenograft Models
For years, mouse tumor models have continuously been used to verify the in vivo efficacy of novel anti-tumor therapeutics in advance of clinical research and testing in humans. Xenograft models, which generally grown in immunodeficient mice (e.g. nude) or severe combined immune deficient (SCID) mice, are the most commonly used models for antineoplastic agents screening. These mouse strains show significant high acceptance rate for xenografts, making them ideal implement for in vivo culture of human tumors.
Applications of Xenograft Models
Xenograft tumor models are usually established by subcutaneous inoculation of a certain number of tumor cells into the flank of mouse/rat. They are normally used to discovery therapeutic schedules, drug dosage and routes of administration, for the sake of maximizing anti-tumor efficacy and therapeutic window.
The following are the xenograft tumor model types you may be interested in:
Cell Line Derived Tumor Xenograft (CDX) Mouse Models
As a vital step in the process of antineoplastic agent discovery, cell line derived tumor xenograft (CDX) models are widely used for preclinical test of drug efficacy, PK/PD correlation, and combination therapy. >>Learn more
Patient-Derived Tumor Xenograft (PDTX) Mouse Models
Patient-derived tumor xenografts, well known as the PDTX or PDX, are based on the transplant of primary tumors from the patient directly into an immunodeficient mouse. >>Learn more
Nude Rat Xenograft Models
Nude rat xenograft models are regarded as an attractive alternative compared with xenograft mouse models, since agents' PK properties in nude rat models are typically similar to that detected in humans. >>Learn more
Why choose us?
At Creative Biolabs, our broad set of xenograft tumor models ensure various assessing alternatives for your oncology agent. Our scientists evaluate the xenograft tumor models on a regular base for the assurance of qualified care standards, which can help to study complete profiling of agents. Creative Biolabs can assist you to select the most appropriate tumor model for your research. If you are interested in learning more about Creative Biolabs' animal models or drug discovery service, please contact us to get exclusive technical support services.
Aiming at providing the most effective and accurate way for our clients to evaluating novel drugs, Creative Biolabs also offers various well-validated rodent tumor models:
For Research Use Only.
