Cell line derived xenografts (CDX) in humanized mouse models has been proven valuable for onco-immunology research, which allows assessment of human tumors under a functional human immune system circumstance. At Creative Biolabs, our various cell line derived xenograft in humanized mouse models are well-characterized and validated, while being proved excellent for anti-cancer drug discovery and onco-immunology studies.
Cell Line Derived Tumor Xenografts in Humanized Mouse Models
Nowadays, the development of immunotherapy studies is obstructed due to the absence of appropriate preclinical animal models. A lot of novel agents are still investigated in evaluation system using murine immunity or murine tumors. However, these models may not precisely reflect the reaction of human immune systems/human tumors to the immunotherapeutic agents. As an essential step in the process of anti-cancer drug discovery, cell line derived tumor xenografts (CDX) models provide significant information to ensure a novel agent keep developing and ensure the researchers to improve the preclinical development projects in a timely and cost-effective method.
Recently, the clinical success of immune checkpoint modulators has facilitated immune-oncology research so as to identify new targets of onco-immunology. Whereas, both drug discovery and target validation require more appropriate models with functional human immune cells or tissues.
Establishment of CDXs in Humanized Mouse
A diverse group of cell lines that stand for a variety of human tumor types are currently available for study. These cell lines are cultured in vitro and can rapidly form tumors after inoculation into immunodeficient mouse which is reconstituted with functional human immune system. The cells may be implanted subcutaneously, intravenously or orthotopically to induce tumors in different microenvironments.
Following is the list of available commonly used human tumor cell lines in Creative Biolabs:
Features of CDXs in Humanized Mouse from Creative Biolabs
Why choose us?
With years of experience in establishing CDXs in humanized mouse models, Creative Biolabs has established a wide range of well-characterized cell line derived xenograft in humanized mouse models and can provide an ideal platform for your research on the screening of potential anti-cancer drugs. A team of senior scientists focused on humanized mouse models can support you to evaluate novel anti-tumor agents in a timely and cost-effective method.
Creative Biolabs also offers other Humanized Mouse Based Tumor Models that may be more appropriate for your research:
If you need to learn more about Creative Biolabs' animal models or drug discovery service, please feel free to contact us for more details.
With advanced technology and extensive experience, Creative Biolabs is proud to offer other common rodent tumor models:
For Research Use Only.
