Patient-derived tumor xenografts (PDTX) in humanized mouse models are effective tools for studying human tumor, infectious disease, hematopoiesis and other common research. This kind of mouse models is supposed to provide significant predictive insight into clinic consequences when assessing the efficacy of novel cancer therapeutics. Creative Biolabs has established a portfolio of PDTX in humanized mouse models with abounding molecular and pharmacological characterization, aiming at providing the most appropriate humanized mouse models for your research.
Patient-Derived Tumor Xenografts in Humanized Mouse Models
Patient-derived tumor xenografts (PDTX) mouse models are commonly used for anti-tumor drug discovery. However, there is one prominent shortcoming of PDTX models that immunodeficient mice must be used to avoid immune attacks against the tumor xenografts. Consequently, a vital component of the given tumor microenvironment interaction is predetermined. Accordingly, PDTX models using immunodeficient mice are not applicable to the studies of immunotherapies and the anti-tumor agents which target the immune system components.
Humanized-xenograft models are developed by combination of engrafting the patient tumor fragment and peripheral blood or bone marrow cells into a NOD, SCID or NSG mouse. The co-engraftment supports the reconstruction of the murine immune system and allows researchers to explore the interactions between tumor microenvironment and xenogenic human stroma in tumor progress and metastasis.
Establishment of PDTXs in Humanized Mouse
Features of PDTX in Humanized Mouse from Creative Biolabs
Patient-derived tumor xenografts (PDTX) in humanized mouse models are considered able to conserve original human tumor characteristics such as malignant phenotypes and genotypes, clinical biomolecular markers, heterogeneous histology, tumor architecture and tumor vasculature. According to this common hypothesis, PDTX in humanized mouse models is supposed to provide significant predictive insight into clinic consequences when assessing the efficacy of novel cancer therapeutics.
Why choose us?
At Creative Biolabs, patient-derived tumor xenografts are established at low passage numbers and never grown in plastic or propagated in vitro as cell cultures. By utilizing the abundant resource of information on PDTXs in humanized mouse models, our scientists can assist you in your oncology research and provide customized humanized mouse models to evaluate your novel anti-cancer agents or cancer immunotherapy.
Creative Biolabs also offers other Humanized Mouse Based Tumor Models you may be interested in:
If you are interested in learning more about Creative Biolabs' animal models or drug discovery service, please do not hesitate to contact us for more details.
In addition, other types of rodent tumor models are also available in Creative Biolabs for our clients to select the most appropriate one for their research:
For Research Use Only.
