APC and Associated Diseases
Creative Biolabs is a reputable biotechnology company focused on providing cutting-edge scientific tools for gene therapy research to assist our clients to achieve remarkable breakthroughs. As a leader in the field of gene therapy, Creative Biolabs is pleased to share background information on the adenomatous polyposis coli (APC) gene.
Overview of APC
APC is defined as a tumor suppressor gene because its alteration is an early event of tumor transformation. It was first discovered in familial adenomatous polyposis (FAP) and has been proven to be related to multiple cancers. APC gene encodes a protein that acts as an antagonist of the Wnt signaling pathway. Furthermore, it is closely related to many cellular activities, including cell migration and apoptosis. APC proteins are complex proteins containing multiple functionally distinct domains.
Fig.1 Functions of APC. (Schneikert, 2007)
Classification of APC Mutations
APC and Associated Diseases
Diseases associated with the APC gene include FAP and gastric cancer.
Related Mechanisms
With advanced technology and a professional team, Creative Biolabs is the perfect choice for your gene therapy projects. If you have any difficulties in the gene therapy project, please contact us in time for reasonable advice and customized solutions.
Reference
- Schneikert, J.; Behrens, J. The canonical Wnt signaling pathway and its APC partner in colon cancer development. Gut. 2007, 56(3): 417-425.